| Herbicide exposure modifies GSTP1 haplotype association to Parkinson onset age: the GenePD Study. | |
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MedLine Citation:
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PMID: 17190945 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Polymorphisms in the glutathione S-transferase pi gene (GSTP1), encoding GSTP1-1, a detoxification enzyme, may increase the risk of Parkinson disease (PD) with exposure to pesticides. Using the GenePD Study sample of familial PD cases, we explored whether GSTP1 polymorphisms were associated with the age at onset of PD symptoms and whether that relation was modified by exposure to herbicides. METHODS: Seven single-nucleotide polymorphisms (SNPs) were genotyped and tested for association with PD onset age in men in three strata: no exposure to herbicides, residential exposure to herbicides, and occupational exposure to herbicides. Haplotypes were similarly evaluated in stratified analyses. RESULTS: Three SNPs were associated with PD onset age in the group of men occupationally exposed to herbicides. Three additional SNPs had significant trends for the association of PD onset age across the herbicide exposure groups. Haplotype results also provided evidence that the relation between GSTP1 and onset age is modified by herbicide exposure. One haplotype was associated with an approximately 8-years-earlier onset in the occupationally exposed group and a 2.8-years-later onset in the nonexposed group. CONCLUSIONS: Herbicide exposure may be an effect modifier of the relation between glutathione S-transferase pi gene polymorphisms and onset age in familial PD. |
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Authors:
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J B Wilk; J E Tobin; O Suchowersky; H A Shill; C Klein; G F Wooten; M F Lew; M H Mark; M Guttman; R L Watts; C Singer; J H Growdon; J C Latourelle; M H Saint-Hilaire; A L DeStefano; R Prakash; S Williamson; C J Berg; M Sun; S Goldwurm; G Pezzoli; B A Racette; J S Perlmutter; A Parsian; K B Baker; M L Giroux; I Litvan; P P Pramstaller; G Nicholson; D J Burn; P F Chinnery; P Vieregge; J T Slevin; F Cambi; M E MacDonald; J F Gusella; R H Myers; L I Golbe |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neurology Volume: 67 ISSN: 1526-632X ISO Abbreviation: Neurology Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-12-27 Completed Date: 2007-01-16 Revised Date: 2012-02-23 |
Medline Journal Info:
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Nlm Unique ID: 0401060 Medline TA: Neurology Country: United States |
Other Details:
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Languages: eng Pagination: 2206-10 Citation Subset: AIM; IM |
Affiliation:
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Department of Neurology, Boston University School of Medicine, 715 Albany St., E-338, Boston, MA 02118, USA. jwilk@bu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Disease Susceptibility
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chemically induced Female Genetic Predisposition to Disease / genetics Glutathione S-Transferase pi / genetics* Haplotypes Herbicides / adverse effects* Humans Male Middle Aged Occupational Diseases / chemically induced*, genetics* Occupational Exposure / adverse effects* Parkinson Disease, Secondary / chemically induced, genetics* Risk Assessment / methods* Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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1S10RR163736-01A1/RR/NCRR NIH HHS; GTF04007//Telethon; R01 NS036711-06/NS/NINDS NIH HHS; R01 NS36711-05/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Herbicides; EC 2.5.1.18/GSTP1 protein, human; EC 2.5.1.18/Glutathione S-Transferase pi |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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