| Herba Cistanche extract enhances mitochondrial glutathione status and respiration in rat hearts, with possible induction of uncoupling proteins. | |
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MedLine Citation:
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PMID: 20645792 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Herba Cistanche, a Chinese herb derived from the whole plant of Cistanche deserticola Y.C. Ma (Orobanchaceae), has been shown to enhance mitochondrial ATP generation and to protect against myocardial ischemia/reperfusion (I/R) injury ex vivo in rats. To define the role of mitochondria in the cardioprotective action of Herba Cistanche, we investigated the effect of Herba Cistanche treatment on mitochondrial glutathione status and functional parameters in rat hearts. Treatment with a methanol extract of Herba Cistanche enhanced mitochondrial glutathione status, decreased mitochondrial Ca(2+) content, and increased mitochondrial membrane potential. In addition, an increase in State 4 respiration, indicative of uncoupled respiration, was observed in mitochondria isolated from Herba Cistanche-treated rat hearts. The enhancement of mitochondrial glutathione status and functional ability, as well as the putative induction of uncoupling proteins, may be related to cardioprotection afforded by Herba Cistanche treatment protecting against I/R injury. |
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Authors:
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Ada Hoi-Ling Siu; Kam Ming Ko |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Pharmaceutical biology Volume: 48 ISSN: 1744-5116 ISO Abbreviation: Pharm Biol Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-07-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9812552 Medline TA: Pharm Biol Country: England |
Other Details:
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Languages: eng Pagination: 512-7 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, Hong Kong University of Science & Technology, Clear Water Bay, Hong Kong SAR, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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