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Hepcidin: A useful marker in chronic obstructive pulmonary disease.
MedLine Citation:
PMID:  22347348     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
PURPOSE: This study was designed to evaluate the levels of hepcidin in the serum of patients with chronic obstructive pulmonary disease (COPD).
METHODS: In the study, 74 male patients (ages 45-75) in a stable period for COPD were grouped as Group I: Mild COPD (n:25), Group II: Moderate COPD (n:24), and Group III: Severe COPD (n:25). Healthy non-smoker males were included in Group IV (n:35) as a control group. The differences of hepcidin level among all the groups were examined. Also, in the patient groups with COPD, hepcidin level was compared with age, body mass index, cigarette (package/year), blood parameters (iron, total iron binding capacity, ferritin, hemoglobin, hematocrit [hct]), respiratory function tests, and arterial blood gas results.
RESULTS: Although there was no difference between the healthy control group and the mild COPD patient group (P=0.781) in terms of hepcidin level, there was a difference between the moderate (P=0.004) and the severe COPD patient groups (P=0.002). The hepcidin level of the control group was found to be higher than the moderate and severe COPD patient groups. In the severe COPD patients, hepcidin level increased with the increase in serum iron (P=0.000), hct (P=0.009), ferritin levels (P=0.012), and arterial oxygen saturation (SaO(2), P=0.000).
CONCLUSION: The serum hepcidin level that is decreased in severe COPD brings into mind that it may play a role in the mechanism to prevent hypoxemia. The results suggest that serum hepcidin level may be a useful marker in COPD. Larger prospective studies are needed to confirm our findings between hepcidin and COPD.
Authors:
Serap Duru; Esra Bilgin; Sadık Ardiç
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of thoracic medicine     Volume:  7     ISSN:  1998-3557     ISO Abbreviation:  Ann Thorac Med     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-02-20     Completed Date:  2012-08-23     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101280721     Medline TA:  Ann Thorac Med     Country:  India    
Other Details:
Languages:  eng     Pagination:  31-5     Citation Subset:  -    
Affiliation:
Diskapi Yildirim Beyazit Education and Research Hospital, Department of Chest Diseases, Ankara, Turkey.
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