| Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. | |
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MedLine Citation:
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PMID: 15514116 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hepcidin is a peptide hormone secreted by the liver in response to iron loading and inflammation. Decreased hepcidin leads to tissue iron overload, whereas hepcidin overproduction leads to hypoferremia and the anemia of inflammation. Ferroportin is an iron exporter present on the surface of absorptive enterocytes, macrophages, hepatocytes, and placental cells. Here we report that hepcidin bound to ferroportin in tissue culture cells. After binding, ferroportin was internalized and degraded, leading to decreased export of cellular iron. The posttranslational regulation of ferroportin by hepcidin may thus complete a homeostatic loop: Iron regulates the secretion of hepcidin, which in turn controls the concentration of ferroportin on the cell surface. |
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Authors:
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Elizabeta Nemeth; Marie S Tuttle; Julie Powelson; Michael B Vaughn; Adriana Donovan; Diane McVey Ward; Tomas Ganz; Jerry Kaplan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. Date: 2004-10-28 |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 306 ISSN: 1095-9203 ISO Abbreviation: Science Publication Date: 2004 Dec |
Date Detail:
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Created Date: 2004-12-17 Completed Date: 2005-01-14 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: United States |
Other Details:
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Languages: eng Pagination: 2090-3 Citation Subset: IM |
Affiliation:
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Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antimicrobial Cationic Peptides / chemical synthesis, genetics, metabolism*, pharmacology Biological Transport Cation Transport Proteins / metabolism* Cell Line Cell Membrane / metabolism Cytosol / metabolism Ferritins / metabolism Hela Cells Homeostasis Humans Iron / metabolism* Iron Regulatory Protein 2 / metabolism Lysosomes / metabolism Mice Protein Binding RNA, Messenger / genetics, metabolism Receptor, Epidermal Growth Factor / metabolism Recombinant Fusion Proteins / metabolism Transfection Transferrin / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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DK065029/DK/NIDDK NIH HHS; DK30534/DK/NIDDK NIH HHS; HL26922/HL/NHLBI NIH HHS; T35HL007744/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antimicrobial Cationic Peptides; 0/Cation Transport Proteins; 0/RNA, Messenger; 0/Recombinant Fusion Proteins; 0/hepcidin; 0/metal transporting protein 1; 11096-37-0/Transferrin; 7439-89-6/Iron; 9007-73-2/Ferritins; EC 2.7.10.1/Receptor, Epidermal Growth Factor; EC 4.2.1.3/Iron Regulatory Protein 2 |
| Comments/Corrections | |
Comment In:
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Science. 2004 Dec 17;306(5704):2051-3
[PMID:
15604397
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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