| Hepcidin and iron metabolism: from laboratory to clinical implications. | |
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MedLine Citation:
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PMID: 20620132 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hepcidin is a liver-synthesized hormone that inhibits the cellular efflux of iron by binding to ferroportin and its subsequent degradation. The main role of hepcidin is regulation of ferroportin expression and cell membrane function. Recent studies implicate hepcidin in a variety of iron disorders in addition to its primary role in the regulation of systemic iron homeostasis. Hepcidin excess has a key pathologic role in anemia of inflammation, chronic kidney disease, and iron-refractory iron deficiency anemia, while hepcidin deficiency is responsible for most cases of familial hemochromatosis and iron-loading anemia. The most important advances on the role of hepcidin in normal and abnormal iron metabolism and the main clinical and diagnostic implications are summarized in this review. |
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Authors:
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Massimo Franchini; Martina Montagnana; Giuseppe Lippi |
Publication Detail:
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Type: Journal Article; Review Date: 2010-07-08 |
Journal Detail:
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Title: Clinica chimica acta; international journal of clinical chemistry Volume: 411 ISSN: 1873-3492 ISO Abbreviation: Clin. Chim. Acta Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-09-13 Completed Date: 2011-01-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1302422 Medline TA: Clin Chim Acta Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1565-9 Citation Subset: IM |
Copyright Information:
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2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Servizio di Immunoematologia e Medicina Trasfusionale, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero-Universitaria di Parma, Italy. mfranchini@ao.pr.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antimicrobial Cationic Peptides
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metabolism*,
physiology Homeostasis Humans Iron / metabolism* Iron Metabolism Disorders / diagnosis, etiology, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Antimicrobial Cationic Peptides; 0/hepcidin; 7439-89-6/Iron |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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