Document Detail


Hepcidin and the iron-infection axis.
MedLine Citation:
PMID:  23139325     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Iron lies at the center of a battle for nutritional resource between higher organisms and their microbial pathogens. The iron status of the human host affects the pathogenicity of numerous infections including malaria, HIV-1, and tuberculosis. Hepcidin, an antimicrobial-like peptide hormone, has emerged as the master regulator of iron metabolism. Hepcidin controls the absorption of dietary iron and the distribution of iron among cell types in the body, and its synthesis is regulated by both iron and innate immunity. We describe how hepcidin integrates signals from diverse physiological inputs, forming a key molecular bridge between iron trafficking and response to infection.
Authors:
Hal Drakesmith; Andrew M Prentice
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  338     ISSN:  1095-9203     ISO Abbreviation:  Science     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-09     Completed Date:  2012-12-03     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  United States    
Other Details:
Languages:  eng     Pagination:  768-72     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Antimicrobial Cationic Peptides / metabolism*
Bacteria / metabolism,  pathogenicity
Hepcidins
Host-Pathogen Interactions
Humans
Immunity, Innate*
Infection / immunology*,  metabolism*,  microbiology
Inflammation / metabolism
Iron / metabolism*
Iron, Dietary / metabolism
Leukocytes / metabolism
Liver / metabolism
Macrophages / metabolism
Signal Transduction
Grant Support
ID/Acronym/Agency:
G0700844//Medical Research Council; G0901149//Medical Research Council; MC-A760-5QX00//Medical Research Council; MC_U123292699//Medical Research Council; MC_U123292700//Medical Research Council; MC_U123292701//Medical Research Council
Chemical
Reg. No./Substance:
0/Antimicrobial Cationic Peptides; 0/HAMP protein, human; 0/Hepcidins; 0/Iron, Dietary; E1UOL152H7/Iron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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