| Hepcidin is correlated to soluble hemojuvelin but not to increased GDF15 during pregnancy. | |
| | |
MedLine Citation:
|
PMID: 22365732 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Increased maternal and foetal iron requirements during pregnancy are compensated by an increase of intestinal iron absorption. Animal studies have shown that the expression of the main iron regulator hepcidin is significantly suppressed during pregnancy, but the factors associated with hepcidin suppression remain unknown. To investigate possible suppressors of hepcidin expression during pregnancy we determined serum concentrations of growth-differentiation factor-15 (GDF15), erythropoietin (EPO), soluble hemojuvelin (HJV) and hepcidin in 42 pregnant women at different time points of gestation and correlated them with serum iron and haematological parameters. Serum iron parameters and serum hepcidin concentration significantly decreased during pregnancy, whereas serum concentrations of GDF15, EPO and soluble HJV significantly increased. A negative correlation of hepcidin with EPO and soluble HJV but no correlation between hepcidin and GDF15 was found. Hepcidin and ferritin were positively correlated throughout the pregnancy. Our findings suggest that hepcidin expression is controlled by body iron stores where soluble HJV and EPO may act as suppressors of hepcidin. |
| | |
Authors:
|
A Finkenstedt; A Widschwendter; C G Brasse-Lagnel; I Theurl; M Hubalek; H Dieplinger; C Tselepis; D G Ward; W Vogel; H Zoller |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-2-24 |
Journal Detail:
|
Title: Blood cells, molecules & diseases Volume: - ISSN: 1096-0961 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
|
Created Date: 2012-2-27 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9509932 Medline TA: Blood Cells Mol Dis Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012. Published by Elsevier Inc. |
Affiliation:
|
Department of Medicine II, Medical University Innsbruck, Innsbruck, Austria. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Determination of lutein by high-performance thin-layer chromatography using densitometry and screeni...
Next Document: Let's Make It Happen: The Role of let-7 MicroRNA in Development.