| Hepcidin: another culprit for complications in patients with chronic kidney disease? | |
| | |
MedLine Citation:
|
PMID: 21785039 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Hepcidin has been established as a central regulator of iron metabolism. In most patients with chronic kidney disease (CKD), serum hepcidin levels are relatively high, favoring iron sequestration in several cell types and organs and thereby leading to iron-related complications. In the absence of overt inflammation, serum hepcidin has been found to be most closely associated with serum ferritin in healthy subjects and in CKD patients. Intestinal iron absorption is tightly regulated by both iron stores and hepcidin. The expression of the mammalian iron exporter, ferroportin (FPN), limits the growth of intracellular bacteria by depleting cytosolic iron. An upregulation of hepcidin could diminish FPN and favor bacterial growth. Of note, in patients with hyperferritinemia impaired hepcidin expression caused by a mutation in the hemochromatosis gene associates with an attenuation of atherosclerosis. Thus, hepcidin might accelerate atherosclerosis by preventing iron exit from macrophages or other cells in the arterial wall. High hepcidin levels have also been found to be linked to good erythropoiesis-stimulating agents (ESAs) response, in conjunction with the strong hepcidin-ferritin correlation. Finally, hepcidin may also play a significant role by itself in the pathogenesis of CKD complications associated with disturbed iron metabolism, i.e. unrelated to ESA hyporesponsiveness, such as bacterial infections and atherosclerosis. |
| | |
Authors:
|
Takeshi Nakanishi; Yukiko Hasuike; Yoshinaga Otaki; Aritoshi Kida; Hiroshi Nonoguchi; Takahiro Kuragano |
Related Documents
:
|
15100949 - Acute necrotizing esophagitis: a large retrospective case series. 19700249 - Association of a globus sensation with esophageal diseases. 8536819 - Abnormal esophagocardiac inhibitory reflex in patients with diffuse esophageal spasm. 18205769 - Barrett's esophagus: a retrospective analysis of 13 years surveillance. 6984219 - Esophageal function after sclerotherapy of bleeding varices. 1495299 - Congenital respiratory-esophageal fistula in the adult. report of nine cases and review... 8930419 - Evoked potential studies in thalamic hemorrhage. 19904219 - Gastric varices in patients with portal hypertension: evaluation with multidetector row... 16684289 - Stevens-johnson syndrome in two patients treated with cranial irradiation and phenytoin. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-7-22 |
Journal Detail:
|
Title: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association Volume: - ISSN: 1460-2385 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
|
Created Date: 2011-7-25 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8706402 Medline TA: Nephrol Dial Transplant Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Internal Medicine, Division of Kidney and Dialysis, Hyogo College of Medicine, Nishinomiya, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: mTOR inhibition and erythropoiesis: microcytosis or anemia?
Next Document: Very early steroid withdrawal or complete avoidance for kidney transplant recipients: a systematic r...