| Hepcidin is produced by lymphoplasmacytic cells and is associated with anemia in Waldenström's macroglobulinemia. | |
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MedLine Citation:
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PMID: 21454222 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Waldenström's macroglobulinemia (WM) patients often present with anemia as their primary disease manifestation that may be related to hepcidin, an important regulator of iron homeostasis. We therefore determined hepcidin levels in 53 WM patients, and 20 age-matched healthy patient donors by hepcidin-25 ELISA. Serum hepcidin levels were elevated in WM patients versus healthy patients (P=.04), and correlated with BM disease involvement (P=.004), beta-2-microglobulin levels (P=.029), and inversely with hemoglobin (P=.05). No correlation with serum iron indices was observed, though in patients with high hepcidin levels, increased iron deposition in bone marrow macrophages was observed. Importantly, hepcidin transcripts and protein were produced by primary WM cells. Hepcidin levels correlated with serum IL-6 (P<.001) and C-Reactive Protein (P=.033) levels. The results of this study implicate hepcidin as a contributor to anemia in WM, and suggest that an iron re-utilization defect accompanies hepcidin overproduction leading to its sequestration in WM patients. |
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Authors:
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Bryan T Ciccarelli; Christopher J Patterson; Zachary R Hunter; Christina Hanzis; Leukothea Ioakimidis; Robert Manning; Guang Yang; Lian Xu; Yangsheng Zhou; Jenny Sun; Xia Liu; Hsiuyi Tseng; Yang Cao; Patricia Sheehy; Scott J Rodig; Steven P Treon |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical lymphoma, myeloma & leukemia Volume: 11 ISSN: 2152-2669 ISO Abbreviation: Clin Lymphoma Myeloma Leuk Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-04-01 Completed Date: 2011-08-30 Revised Date: 2011-10-03 |
Medline Journal Info:
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Nlm Unique ID: 101525386 Medline TA: Clin Lymphoma Myeloma Leuk Country: United States |
Other Details:
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Languages: eng Pagination: 160-3 Citation Subset: IM |
Affiliation:
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Bing Center for Waldenstrom's Macroglobulinemia, Dana Farber Cancer Institute, Harvard Medical School, Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Anemia / blood* Antimicrobial Cationic Peptides / blood* Female Humans Lymphocytes / metabolism Male Middle Aged Plasma Cells / metabolism Waldenstrom Macroglobulinemia / blood* |
| Chemical | |
Reg. No./Substance:
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0/Antimicrobial Cationic Peptides; 0/hepcidin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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