| Hepatotoxicosis in dogs consuming a diet of camel meat contaminated with indospicine. | |
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MedLine Citation:
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PMID: 21323657 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background Four dogs presented with clinical signs of severe hepatic disease after consuming a commercial camel meat diet. Methods Laboratory investigation revealed evidence of severe liver disease, including markedly increased serum alanine aminotransferase (ALT) activity and total bilirubin concentration, and prolonged clotting times. Results Two dogs deteriorated despite supportive therapy and were euthanased. Histologically, both livers appeared similar, with the main lesion being extensive periacinar necrosis and haemorrhage. Indospicine, a toxic amino acid of plant origin, was detected in the serum and/or plasma from all four dogs, as well as in tissues of a dog that was necropsied and in a sample of the camel meat fed to this animal. Serum biochemistry tests using blood samples collected from 15 additional dogs identified as having eaten the diet detected indospicine was in the serum of 14 and 3 had increased ALT activity. One of the latter dogs subsequently developed clinical signs of severe liver disease and was euthanased. Conclusion To the authors' knowledge, this is the first published report of the detection of indospicine residues in camel meat and the occurrence of severe, sometimes fatal, liver disease in dogs that consumed this contaminated meat. |
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Authors:
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Lm Fitzgerald; Mt Fletcher; Aeh Paul; Cs Mansfield; Aj O'Hara |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Australian veterinary journal Volume: 89 ISSN: 1751-0813 ISO Abbreviation: Aust. Vet. J. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370616 Medline TA: Aust Vet J Country: Australia |
Other Details:
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Languages: eng Pagination: 95-100 Citation Subset: IM |
Copyright Information:
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© 2011 The Authors. Australian Veterinary Journal © 2011 Australian Veterinary Association. |
Affiliation:
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School of Veterinary and Biomedical Sciences, Division of Health Sciences, Murdoch University, South Street, Murdoch, Western Australia 6150, Australia; L.FitzGerald@murdoch.edu.au Animal Research Institute, Department of Employment, Economic Development and Innovation, Moorooka, Queensland, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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