Document Detail

Hepatotoxicosis in dogs consuming a diet of camel meat contaminated with indospicine.
MedLine Citation:
PMID:  21323657     Owner:  NLM     Status:  In-Data-Review    
Background  Four dogs presented with clinical signs of severe hepatic disease after consuming a commercial camel meat diet. Methods  Laboratory investigation revealed evidence of severe liver disease, including markedly increased serum alanine aminotransferase (ALT) activity and total bilirubin concentration, and prolonged clotting times. Results  Two dogs deteriorated despite supportive therapy and were euthanased. Histologically, both livers appeared similar, with the main lesion being extensive periacinar necrosis and haemorrhage. Indospicine, a toxic amino acid of plant origin, was detected in the serum and/or plasma from all four dogs, as well as in tissues of a dog that was necropsied and in a sample of the camel meat fed to this animal. Serum biochemistry tests using blood samples collected from 15 additional dogs identified as having eaten the diet detected indospicine was in the serum of 14 and 3 had increased ALT activity. One of the latter dogs subsequently developed clinical signs of severe liver disease and was euthanased. Conclusion  To the authors' knowledge, this is the first published report of the detection of indospicine residues in camel meat and the occurrence of severe, sometimes fatal, liver disease in dogs that consumed this contaminated meat.
Lm Fitzgerald; Mt Fletcher; Aeh Paul; Cs Mansfield; Aj O'Hara
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Australian veterinary journal     Volume:  89     ISSN:  1751-0813     ISO Abbreviation:  Aust. Vet. J.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370616     Medline TA:  Aust Vet J     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  95-100     Citation Subset:  IM    
Copyright Information:
© 2011 The Authors. Australian Veterinary Journal © 2011 Australian Veterinary Association.
School of Veterinary and Biomedical Sciences, Division of Health Sciences, Murdoch University, South Street, Murdoch, Western Australia 6150, Australia; Animal Research Institute, Department of Employment, Economic Development and Innovation, Moorooka, Queensland, Australia.
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