| Hepatotoxicity testing of atracurium and laudanosine in the isolated, perfused rat liver. | |
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MedLine Citation:
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PMID: 1389846 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The pharmacokinetics of atracurium, which is degraded by Hofmann decomposition and ester hydrolysis, is not altered by impaired liver function. Atracurium should, therefore, be ideal for patients with heptic failure, and is now widely used in clinical practice. However, some studies reported considerable hepatotoxicity after atracurium, especially from its breakdown products--for example, leakage of lactate dehydrogenase (LDH) from isolated rat hepatocytes. Therefore, we have studied, in an isolated perfused rat liver model, biochemical and morphological changes after administration of either atracurium or its main metabolite, laudanosine. Despite using extremely high concentrations of these substances, we could not detect, biochemically (release of LDH or aspartate amino-transferase (AST)) or histologically, any signs of liver cell damage. |
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Authors:
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H Reckendorfer; H Burgmann; M Sperlich; G L Tüchy; W Feigl; P G Spieckermann; M Weindlmayr-Göttel; S Schwarz |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: British journal of anaesthesia Volume: 69 ISSN: 0007-0912 ISO Abbreviation: Br J Anaesth Publication Date: 1992 Sep |
Date Detail:
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Created Date: 1992-11-05 Completed Date: 1992-11-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372541 Medline TA: Br J Anaesth Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 288-91 Citation Subset: IM |
Affiliation:
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Department of Pathology, Allgem. Poliklinik, Vienna, Austria. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aspartate Aminotransferases / metabolism Atracurium / adverse effects*, metabolism Bile / metabolism Isoquinolines / adverse effects*, metabolism L-Lactate Dehydrogenase / metabolism Liver / drug effects*, metabolism Male Organ Culture Techniques Rats |
| Chemical | |
Reg. No./Substance:
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0/Isoquinolines; 2688-77-9/laudanosine; 64228-79-1/Atracurium; EC 1.1.1.27/L-Lactate Dehydrogenase; EC 2.6.1.1/Aspartate Aminotransferases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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