Document Detail

Hepatotoxicity related to total parenteral nutrition: comparison of low-lipid and lipid-supplemented solutions.
MedLine Citation:
PMID:  7920977     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Because it is unclear whether or not the lipid or carbohydrate component of total parenteral nutrition solutions determines the development of cholestasis during total parenteral nutrition, a prospective randomized clinical trial of a predominantly carbohydrate solution (group I) versus one with isocaloric substitution of 30% nonprotein calories with lipid (group II) was performed. METHODS: Twelve patients in group I, 4 female and 8 male, and 14 patients in group II, 8 female and 6 male, were studied. Each subject received 100% to 150% of the basal energy needs, determined by the Harris-Benedict equation. Amino acids were supplied to provide a protein:kilocalorie ratio of 1:150 to 200. There were no differences between the groups in terms of mortality, nitrogen balance, and maintenance of weight. Weekly serum aspartate aminotrasferase (AST) and alkaline phosphatase (AP) levels were obtained. The change from baseline values was calculated. RESULTS: The observed difference between the two groups for AST was 5.7 (higher for group II), P = .55, and for AP, 39.1 (higher for group I), P = .23. A power calculation was performed to determine the number of patients required for a statistically significant difference in AP between the two groups with an alpha of 0.05 and a power of 0.85:67 patients. CONCLUSIONS: With these statistical considerations, we conclude that there was probably no statistically significant difference between the groups for an increase in AST or AP levels during total parenteral nutrition.
R M Craig; D Coy; R Green; R Meersman; H Rubin; I Janssen
Related Documents :
24257657 - Efficacy and safety of fibrin glue and tranexamic acid to prevent postoperative blood l...
20739147 - Treatment with growth hormone, somatostatin, and insulin in combination with hypocalori...
7920977 - Hepatotoxicity related to total parenteral nutrition: comparison of low-lipid and lipid...
25017117 - A uk single centre retrospective analysis of the relationship between haemodynamic chan...
22859567 - Risk factors for rectal bleeding associated with i-125 brachytherapy for prostate cancer.
25295267 - Comparison of proton pump inhibitor and histamine-2 receptor antagonist in the preventi...
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Journal of critical care     Volume:  9     ISSN:  0883-9441     ISO Abbreviation:  J Crit Care     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-11-04     Completed Date:  1994-11-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8610642     Medline TA:  J Crit Care     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  111-3     Citation Subset:  IM    
Department of Medicine, Northwestern University Medical Center, Chicago, Illinois 60611.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Alkaline Phosphatase / blood
Aspartate Aminotransferases / blood
Bias (Epidemiology)
Carbohydrates / adverse effects*
Cholestasis / blood,  chemically induced*,  epidemiology
Energy Intake*
Energy Metabolism
Fat Emulsions, Intravenous / adverse effects*
Parenteral Nutrition, Total / adverse effects*
Prospective Studies
Grant Support
Reg. No./Substance:
0/Carbohydrates; 0/Fat Emulsions, Intravenous; EC Aminotransferases; EC Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The effect of positive end-expiratory pressure on regional pulmonary perfusion during acute lung inj...
Next Document:  Implications of a biphasic two-compartment model of constant flow ventilation for the clinical setti...