Document Detail

Hepatotoxicity and persistent renal insufficiency after repeated supratherapeutic paracetamol ingestion in a Chinese boy.
MedLine Citation:
PMID:  14967859     Owner:  NLM     Status:  MEDLINE    
Paracetamol has always been regarded as a useful and safe drug. The risk of toxicity with repeated supratherapeutic paracetamol is an underrecognised condition. We report on a 12-month-old boy who presented with hepatotoxicity, disseminated intravascular coagulation and persistent renal insufficiency 4 days after repeated ingestion of a supratherapeutic dosage of paracetamol. To the best of our knowledge, this is the first reported case of paediatric chronic paracetamol poisoning among the Chinese population. In addition, persistent renal insufficiency has not been a previously reported feature of chronic paracetamol poisoning. We propose that renal damage is the result of the synergistic effect of hypoperfusion and paracetamol overdose.
K L Kwok; Y M Fu; D K K Ng
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Hong Kong medical journal = Xianggang yi xue za zhi / Hong Kong Academy of Medicine     Volume:  10     ISSN:  1024-2708     ISO Abbreviation:  Hong Kong Med J     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-02-17     Completed Date:  2004-06-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9512509     Medline TA:  Hong Kong Med J     Country:  China    
Other Details:
Languages:  eng     Pagination:  61-4     Citation Subset:  IM    
Department of Paediatrics, Kwong Wah Hospital, 25 Waterloo Road, Kowloon, Hong Kong.
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MeSH Terms
Acetaminophen / administration & dosage,  adverse effects*
Analgesics, Non-Narcotic / administration & dosage,  adverse effects*
Dose-Response Relationship, Drug
Glomerular Filtration Rate / drug effects
Kidney / drug effects*
Liver / drug effects*
Respiratory Tract Infections / drug therapy
Shock / etiology
Reg. No./Substance:
0/Analgesics, Non-Narcotic; 103-90-2/Acetaminophen
Comment In:
Hong Kong Med J. 2004 Jun;10(3):220-1; author reply 221-2   [PMID:  15181232 ]
Hong Kong Med J. 2004 Jun;10(3):220; author reply 221-2   [PMID:  15181231 ]

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