Document Detail

Hepatotoxicity and liver enzyme alteration in patients with immunobullous diseases receiving immunosuppressive therapy.
MedLine Citation:
PMID:  21981904     Owner:  NLM     Status:  Publisher    
To avoid complications of high dose corticosteroid, pemphigus patients are usually co-treated with other immunosuppressive agents. Liver enzyme abnormality occurs commonly during treatment and occasionally causes discontinuation of drugs. To assess the rate of therapy-induced hepatotoxicity in patients with immunobullous diseases, we conducted a study of 250 pemphigus patients under immunosuppressive therapy prospectively. Aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) plasma levels were recorded before the start of treatment and every week under treatment (up to 3 weeks). Hepatotoxicity was defined as the rise in the ALT plasma levels to greater than twice the upper normal limit. Approximately 81% of patients received prednisolone and azathioprine. Approximately 12% received only prednisolone. Hepatotoxicity occurred in 2.9% (n = 8) of patients after 1 week, in 7.8% (n = 20) after 2 weeks and in 11.5% (n = 29) after 3 weeks. No patient had jaundice or other clinical manifestations of hepatitis. The mean values of ALT and AST before the start of treatment were 20.7 ± 13.7 and 17.6 ± 10.8 U/L, respectively that grew to 47.5 ± 28.5 and 26.8 ± 14.5 U/L, 3 weeks after the initiation of treatment. Distribution of changes was not significantly different among groups of age, sex, immunosuppressive drugs and isoniazid consumption. Under usual treatment of pemphigus, hepatotoxicity occurs in 10% of patients during the first 3 weeks of therapy that does not seem to be associated with azathioprine or mycophenolate mofetil exclusively. High doses of prednisolone may play a role.
Mostafa M Shahshahani; Sahar Azizahari; Tahere Soori; Saeed Manavi; Kamran Balighi; Maryam Daneshpazhooh; Cheida S Davatchi; Nasife Esmaili
Related Documents :
21973194 - A randomized, observer-blinded, comparison of combined 1064-nm q-switched neodymium-dop...
9798804 - Ranitidine bismuth citrate (rbc) based triple therapy for 7 days is more effective than...
8284634 - Long-term omeprazole therapy does not affect helicobacter pylori status in most patients.
25308924 - Efficacy of topical tacrolimus for oral lichen planus: real-life experience in a retros...
22017324 - Leptospirosis-associated acute kidney injury: penicillin at the late stage is still con...
1536734 - Nephrotic syndrome in 1st year of life and the role of unilateral nephrectomy.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-10
Journal Detail:
Title:  The Journal of dermatology     Volume:  -     ISSN:  1346-8138     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600545     Medline TA:  J Dermatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 Japanese Dermatological Association.
Department of Dermatology Razi Immunobullous Diseases Research Center Tehran University of Medical Sciences, Tehran, Iran.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Security of attachment and quality of mother-toddler social interaction in a high-risk sample.
Next Document:  Greasing the wheels of managing overweight and obesity with omega-3 fatty acids.