| Hepatotoxicity from antithyroid drugs. | |
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MedLine Citation:
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PMID: 4007783 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We review the cases of hepatic injury from propylthiouracil, methimazole and carbimazole in the English language literature and compare them to cases of agranulocytosis in a recent review. The data on hepatotoxicity confirm the findings for agranulocytosis that low-dose methimazole is safer than propylthiouracil and that methimazole toxicity is more common over 40 years old. In contrast, propylthiouracil hepatotoxicity often occurs in younger patients. Most cases of hepatic injury occur in the first few months of drug therapy as with agranulocytosis. The reason that methimazole typically causes cholestatic hepatitis while propylthiouracil causes cytotoxic hepatitis remains unknown. |
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Authors:
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A C Vitug; J M Goldman |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Hormone research Volume: 21 ISSN: 0301-0163 ISO Abbreviation: Horm. Res. Publication Date: 1985 |
Date Detail:
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Created Date: 1985-08-12 Completed Date: 1985-08-12 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0366126 Medline TA: Horm Res Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 229-34 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Agranulocytosis / chemically induced Carbimazole / adverse effects* Child Drug-Induced Liver Injury* Female Humans Male Methimazole / adverse effects* Middle Aged Propylthiouracil / adverse effects* |
| Chemical | |
Reg. No./Substance:
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22232-54-8/Carbimazole; 51-52-5/Propylthiouracil; 60-56-0/Methimazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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