Document Detail


Hepatotoxicity associated with cocaine abuse.
MedLine Citation:
PMID:  1589605     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mechanisms evaluated in animals as being responsible for cocaine associated hepatotoxicity are presented. The importance of the P-450 enzyme system in cocaine associated hepatotoxicity is emphasized. Moreover, the putative critical role of free radicals in such injury is discussed. Finally, the growing literature on clinical cases of cocaine hepatotoxicity is reviewed.
Authors:
D H Van Thiel; J A Perper
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism     Volume:  10     ISSN:  0738-422X     ISO Abbreviation:  Recent Dev Alcohol     Publication Date:  1992  
Date Detail:
Created Date:  1992-06-22     Completed Date:  1992-06-22     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8301996     Medline TA:  Recent Dev Alcohol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  335-41     Citation Subset:  IM    
Affiliation:
Department of Surgery, University of Pittsburgh School of Medicine, Pennsylvania 15213.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cocaine / adverse effects*,  pharmacokinetics
Cytochrome P-450 Enzyme System / physiology
Drug-Induced Liver Injury / enzymology,  etiology*
Humans
Risk Factors
Substance-Related Disorders / complications*,  enzymology,  rehabilitation
Grant Support
ID/Acronym/Agency:
AA04425/AA/NIAAA NIH HHS; AA06601/AA/NIAAA NIH HHS; DK32556/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
50-36-2/Cocaine; 9035-51-2/Cytochrome P-450 Enzyme System

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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