| Hepatotoxicity associated with chinese skullcap contained in Move Free Advanced dietary supplement: two case reports and review of the literature. | |
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MedLine Citation:
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PMID: 20586134 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Move Free Advanced is a widely available dietary supplement in the United States, marketed to comfort sore joints and improve flexibility and mobility. This product contains glucosamine, chondroitin, hyaluronic acid, and Uniflex proprietary extract, which is a combination of Chinese skullcap and black catechu. We describe two patients who developed hepatotoxicity after ingesting a Move Free Advanced product. In both patients, the hepatotoxicity resolved after discontinuation of the supplement. Use of the Naranjo adverse drug reaction probability scale indicated a probable relationship (score of 6 for both patients) between the patients' development of hepatotoxicity and the Move Free Advanced supplement. Based on a review of the literature, the herbal extract Chinese skullcap is the most likely cause of the hepatotoxicity. To our knowledge, these two cases are the first to be published regarding possible hepatotoxicity associated with Move Free Advanced. Patients seeking dietary supplements for osteoarthritis may want to avoid glucosaminechondroitin products such as Move Free Advanced that also contain Chinese skullcap. |
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Authors:
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Sunny A Linnebur; Olivia C Rapacchietta; Maria Vejar |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Pharmacotherapy Volume: 30 ISSN: 1875-9114 ISO Abbreviation: Pharmacotherapy Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-29 Completed Date: 2010-10-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8111305 Medline TA: Pharmacotherapy Country: United States |
Other Details:
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Languages: eng Pagination: 750, 258e-262e Citation Subset: IM |
Affiliation:
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School of Pharmacy, University of Colorado Denver, Aurora, Colorado 80045, USA. sunny.linnebur@ucdenver.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Chondroitin Sulfates Dietary Supplements / adverse effects* Drug-Induced Liver Injury / etiology* Glucosamine Humans United States |
| Chemical | |
Reg. No./Substance:
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3416-24-8/Glucosamine; 9007-28-7/Chondroitin Sulfates |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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