Document Detail

Hepatotoxicity of amiodarone.
MedLine Citation:
PMID:  1295429     Owner:  NLM     Status:  MEDLINE    
Amiodarone, a commonly used antiarrhythmic agent, has numerous adverse effects. The purpose of this case report is to highlight its hepatotoxicity, an unusual complication of long term amiodarone therapy. Our patient is a 76-year-old man with underlying ischaemic heart disease and recurrent ventricular tachycardia. Eleven months after commencing amiodarone, he developed asymptomatic raised aminotransferases which resolved following drug withdrawal. Amiodarone was then reintroduced and four years later, the patient developed hepatomegaly, worsening liver biochemistry and histopathological changes consistent with early cirrhosis. His symptoms improved following discontinuation of amiodarone. However, hepatomegaly and a low serum albumin still persist four years later.
R Jeyamalar; R Pathmanathan; D Wong; P Kannan
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Annals of the Academy of Medicine, Singapore     Volume:  21     ISSN:  0304-4602     ISO Abbreviation:  Ann. Acad. Med. Singap.     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1993-04-12     Completed Date:  1993-04-12     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7503289     Medline TA:  Ann Acad Med Singapore     Country:  SINGAPORE    
Other Details:
Languages:  eng     Pagination:  838-40     Citation Subset:  IM    
Department of Medicine, University Hospital, Kuala Lumpur, Malaysia.
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MeSH Terms
Amiodarone / administration & dosage,  adverse effects*
Coronary Disease / drug therapy*,  pathology
Drug-Induced Liver Injury / pathology*
Follow-Up Studies
Liver / pathology
Liver Function Tests
Tachycardia, Ventricular / drug therapy*,  pathology
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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