Document Detail


Hepatotoxicity of alpha-methyldopa in pregnancy.
MedLine Citation:
PMID:  20831537     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Alpha-methyldopa is one of the most widely prescribed antihypertensive agents used during pregnancy. Despite its known potential hepatotoxicity, there have been only a few reports describing hepatotoxicity with the use of this drug during pregnancy. We report here a new case of acute hepatitis in a pregnant woman related to the use of alpha-methyldopa, and briefly review the literature on alpha-methyldopa-induced hepatotoxicity in pregnancy.
Authors:
R Slim; C Ben Salem; H Hmouda; K Bouraoui
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of clinical pharmacy and therapeutics     Volume:  35     ISSN:  1365-2710     ISO Abbreviation:  J Clin Pharm Ther     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-09-13     Completed Date:  2010-12-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8704308     Medline TA:  J Clin Pharm Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  361-3     Citation Subset:  IM    
Affiliation:
Department of Clinical Pharmacology, Faculty of Medicine of Sousse, Tunisia. raoudha_slim3@yahoo.fr
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adult
Antihypertensive Agents / adverse effects*,  therapeutic use
Drug-Induced Liver Injury / etiology*
Female
Humans
Hypertension, Pregnancy-Induced / drug therapy
Methyldopa / adverse effects*,  therapeutic use
Pregnancy
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 555-30-6/Methyldopa

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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