| Hepatotoxicity after transarterial chemoembolization and transjugular intrahepatic portosystemic shunt: do two rights make a wrong? | |
MedLine Citation:
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PMID: 23176968 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To compare the rates of hepatotoxicity after transarterial chemoembolization for hepatocellular carcinoma (HCC) in patients with and without a transjugular intrahepatic portosystemic shunt (TIPS) who were stratified into comparable risk groups. MATERIALS AND METHODS: A retrospective review of patients with HCC who were treated with transarterial chemoembolization between January 2005 and December 2009 was performed. Of 158 patients with comparable model for end-stage liver disease (MELD) scores, 10 had a patent TIPS. Hepatobiliary severe adverse events (SAEs) occurring after transarterial chemoembolization were documented. In addition, 1-year survival and liver transplantation rate after transarterial chemoembolization were calculated in each group. RESULTS: The incidence of hepatobiliary SAEs after transarterial chemoembolization was nearly two times higher in patients with a TIPS (70%) than in patients without a TIPS (36%; P=.046). The liver transplantation rate 1 year after transarterial chemoembolization was 2.5 times higher in patients with a TIPS (80%) than in patients without a TIPS (32%; P=.004). There was no significant difference in 1-year survival between the two groups after transarterial chemoembolization. CONCLUSIONS: Patients with HCC and a patent TIPS are more likely to develop significant hepatotoxicity after transarterial chemoembolization than comparable patients without a TIPS in place. |
Authors:
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Maureen P Kohi; Nicholas Fidelman; David M Naeger; Jeanne M LaBerge; Roy L Gordon; Robert K Kerlan |
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Publication Detail:
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Type: Controlled Clinical Trial; Journal Article Date: 2012-11-22 |
Journal Detail:
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Title: Journal of vascular and interventional radiology : JVIR Volume: 24 ISSN: 1535-7732 ISO Abbreviation: J Vasc Interv Radiol Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2012-12-31 Completed Date: 2013-07-09 Revised Date: 2013-08-19 |
Medline Journal Info:
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Nlm Unique ID: 9203369 Medline TA: J Vasc Interv Radiol Country: United States |
Other Details:
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Languages: eng Pagination: 68-73 Citation Subset: IM |
Copyright Information:
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Copyright © 2013 SIR. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA 94143, USA. maureen.kohi@ucsf.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over California / epidemiology Carcinoma, Hepatocellular / mortality*, therapy* Chemoembolization, Therapeutic / mortality* Combined Modality Therapy Comorbidity Drug-Induced Liver Injury / mortality* Female Humans Incidence Liver Neoplasms / mortality*, therapy* Male Middle Aged Portasystemic Shunt, Transjugular Intrahepatic / mortality* Risk Factors Survival Analysis Survival Rate |
| Comments/Corrections | |
Comment In:
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J Vasc Interv Radiol. 2013 Jul;24(7):1075-6
[PMID:
23796100
]
J Vasc Interv Radiol. 2013 Jul;24(7):1076 [PMID: 23796101 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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