| Hepatotoxicity after high-dose methylprednisolone for demyelinating disease. | |
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MedLine Citation:
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PMID: 19935411 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Liver toxicity, although not mentioned among the possible adverse effects of corticosteroids, has been occasionally reported in literature. We observed 2 cases of hepatotoxicity after a high-dose methylprednisolone treatment of a demyelinating disease and evaluated the potential relationship in the light of available evidence. The first patient developed a histologically documented acute hepatitis and recovered after 3 weeks. In the second patient, a mild augmentation of liver enzymes occurred, followed by normalization in a few days. The causal relationship between hepatotoxicity and methylprednisolone treatment was deemed probable in both cases. Careful review of the literature suggests that corticosteroid-induced liver damage may be more frequent than commonly believed. |
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Authors:
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Anna Loraschi; Paola Banfi; Marco Mauri; Fausto Sessa; Giorgio Bono; Marco Cosentino |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Clinical neuropharmacology Volume: 33 ISSN: 1537-162X ISO Abbreviation: Clin Neuropharmacol Publication Date: 2010 Jan-Feb |
Date Detail:
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Created Date: 2010-02-03 Completed Date: 2010-04-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7607910 Medline TA: Clin Neuropharmacol Country: United States |
Other Details:
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Languages: eng Pagination: 52-4 Citation Subset: IM |
Affiliation:
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Section of Experimental and Clinical Pharmacology, Department of Clinical Medicine, Varese, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anti-Inflammatory Agents / adverse effects*, therapeutic use* Demyelinating Diseases / drug therapy Drug Toxicity / chemically induced Drug-Induced Liver Injury / etiology* Female Humans Male Methylprednisolone / adverse effects*, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 83-43-2/Methylprednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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