| Hepatorenal syndrome: an update. | |
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MedLine Citation:
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PMID: 17505686 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hepatorenal syndrome (HRS) is the development of renal failure in patients with chronic previous liver disease, without clinical or laboratory evidence of previous kidney disease. It affects up to 18% of cirrhotic patients with ascites during the first year of follow-up, reaching 39% in five years and presenting a survival of about two weeks after its establishment. HRS diagnosis is based on clinical and laboratory data. The occurrence of this syndrome is related to the mechanism for ascites development, involving vasoconstriction, low renal perfusion, water and sodium retention, increased plasma volume, and consequent overflow at the splanchnic level. Renal vasoactive mediators like endothelin 1, thromboxane A2, and leukotrienes are also involved in the genesis of this syndrome, which culminates in functional renal insufficiency. The treatment of choice can be pharmacological or surgical, although liver transplantation is the only permanent and effective treatment, with a four-year survival rate of up to 60%. Liver function recovery is usually followed by renal failure reversion. Early diagnosis and timely therapeutics can increase life expectancy for these patients while they are waiting for liver transplantation as a definitive treatment. |
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Authors:
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Tércio Genzini; Fábio César Miranda Torricelli |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: São Paulo medical journal = Revista paulista de medicina Volume: 125 ISSN: 1516-3180 ISO Abbreviation: Sao Paulo Med J Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2007-05-16 Completed Date: 2008-02-28 Revised Date: 2009-01-26 |
Medline Journal Info:
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Nlm Unique ID: 100897261 Medline TA: Sao Paulo Med J Country: Brazil |
Other Details:
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Languages: eng Pagination: 50-6 Citation Subset: IM |
Affiliation:
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HEPATO, Hospital Beneficiencia Portuguesa, São Paulo, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Ascites
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complications Hepatorenal Syndrome* / diagnosis, etiology, therapy Humans Liver Transplantation Vasoconstriction |
| Comments/Corrections | |
Comment In:
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Sao Paulo Med J. 2008 Jan 2;126(1):67; author reply 67
[PMID:
18425291
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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