| Hepatoprotective effects of immobilized granulocyte colony-stimulating factor and hyaluronidase preparation and their mechanisms. | |
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MedLine Citation:
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PMID: 22808511 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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High hepatoprotective activity of granulocytic CSF and hyaluronidase immobilized using electron-beam immobilization technology was demonstrated on the model of CCl(4)-induced hepatitis: the preparations produced anticholestatic, anti-inflammatory, and antisclerotic effects. These effects developed against the background of stimulation of bone marrow multipotent precursor cells and their mobilization into circulation accompanied by an increase in the content of parenchymatous progenitor cells in the liver. The most pronounced positive effect was observed in combined treatment with the test preparations. |
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Authors:
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A M Dygai; V V Zhdanov; G N Zyuzkov; L A Stavrova; L A Miroshnichenko; E V Udut; T Yu Khrichkova; E V Simanina; A V Artamonov; A A Bekarev; P G Madonov; D N Kinsht; R V Gurto; A V Chaikovskiy; T S Markova; T I Fomina; L A Ermolaeva; T V Vetoshkina; T Yu Dubskaya |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Bulletin of experimental biology and medicine Volume: 153 ISSN: 1573-8221 ISO Abbreviation: Bull. Exp. Biol. Med. Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-07-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372557 Medline TA: Bull Exp Biol Med Country: United States |
Other Details:
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Languages: eng; rus Pagination: 129-33 Citation Subset: IM |
Affiliation:
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Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk; Scientific Future Management Company, Novosibirsk, Russia. zw@pharm.tsu.ru. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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