Document Detail


Hepatoprotective effects of immobilized granulocyte colony-stimulating factor and hyaluronidase preparation and their mechanisms.
MedLine Citation:
PMID:  22808511     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
High hepatoprotective activity of granulocytic CSF and hyaluronidase immobilized using electron-beam immobilization technology was demonstrated on the model of CCl(4)-induced hepatitis: the preparations produced anticholestatic, anti-inflammatory, and antisclerotic effects. These effects developed against the background of stimulation of bone marrow multipotent precursor cells and their mobilization into circulation accompanied by an increase in the content of parenchymatous progenitor cells in the liver. The most pronounced positive effect was observed in combined treatment with the test preparations.
Authors:
A M Dygai; V V Zhdanov; G N Zyuzkov; L A Stavrova; L A Miroshnichenko; E V Udut; T Yu Khrichkova; E V Simanina; A V Artamonov; A A Bekarev; P G Madonov; D N Kinsht; R V Gurto; A V Chaikovskiy; T S Markova; T I Fomina; L A Ermolaeva; T V Vetoshkina; T Yu Dubskaya
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bulletin of experimental biology and medicine     Volume:  153     ISSN:  1573-8221     ISO Abbreviation:  Bull. Exp. Biol. Med.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-07-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372557     Medline TA:  Bull Exp Biol Med     Country:  United States    
Other Details:
Languages:  eng; rus     Pagination:  129-33     Citation Subset:  IM    
Affiliation:
Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk; Scientific Future Management Company, Novosibirsk, Russia. zw@pharm.tsu.ru.
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