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Hepatoprotective activity of ginsenosides from Panax ginseng adventitious roots against carbon tetrachloride treated hepatic injury in rats.
MedLine Citation:
PMID:  25446594     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
ETHNOPHARMACOLOGICAL RELEVANCE: Ginseng (Panax ginseng C. A. Meyer) has a beneficial role in the treatment of various diseases including liver disorders like acute/chronic hepatotoxicity, hepatitis, hepatic fibrosis/cirrhosis and hepatocellular carcinoma.
MATERIALS AND METHODS: Tissue culture raised mountain ginseng adventitious root (TCMGARs) extract with ginsenosides in abundance was used as an experimental material. 'Sprague-Dawley' male rats were used as experimental systems and were fed with TCMGARs extracts at doses of 30, 100, 300mg/kg body weight for two weeks to test the effect on carbon tetrachloride (CCl4) induced acute liver damage. Field cultivated Korean ginseng root extract fed rats (100mg/kg) were used as positive control. Plasma enzyme levels, alanine aminotranferase (ALT), aspartate aminotranferase (AST) and alkaline phosphatase (ALP) were assessed. Glutathione (GSH) and malondialdehyde (MDA) concentrations were also evaluated.
RESULTS: TCMGARs extracts remarkably prevented the elevation of ALT, AST, ALP and liver peroxides in CCl4-treated rats. Hepatic glutathione levels were significantly increased by the treatment with the extracts in experimental groups.
CONCLUSION: The TCMGARs rich in varied ginsenosides can afford protection against CCl4-induced hepatocellular injury.
Authors:
Hosakatte Niranjana Murthy; Vijayalaxmi S Dandin; Kee Yoeup Paek
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-10-31
Journal Detail:
Title:  Journal of ethnopharmacology     Volume:  158PA     ISSN:  1872-7573     ISO Abbreviation:  J Ethnopharmacol     Publication Date:  2014 Oct 
Date Detail:
Created Date:  2014-12-2     Completed Date:  -     Revised Date:  2014-12-3    
Medline Journal Info:
Nlm Unique ID:  7903310     Medline TA:  J Ethnopharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  442-446     Citation Subset:  -    
Copyright Information:
Copyright © 2014. Published by Elsevier Ireland Ltd.
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