| Hepatoprotective activity of Phyllanthus reticulatus. | |
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MedLine Citation:
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PMID: 18930851 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two partially purified organic fractions designated by PR1 and PR2 of the fat free ethanol (95%) extract of aerial parts of Phyllanthus reticulatus were tested for the hepatoprotective activity in rats against CCl(4)-induced liver damage. The rats receiving the fractions showed promising hepatoprotective activity as evident from significant changes of pentobarbital-induced sleeping time, changes in serum levels of sGPT, sGOT, sALP and bilirubin and also from histopathological changes as compared to CCl(4)-intoxicated rats. |
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Authors:
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Biplab K Das; Sukumar Bepary; Bidyut K Datta; Ak Azad Chowdhury; Mohammad Shawkat Ali; Abu Shara Shamsur Rouf |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pakistan journal of pharmaceutical sciences Volume: 21 ISSN: 1011-601X ISO Abbreviation: Pak J Pharm Sci Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-10-20 Completed Date: 2008-12-22 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9426356 Medline TA: Pak J Pharm Sci Country: Pakistan |
Other Details:
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Languages: eng Pagination: 333-7 Citation Subset: IM |
Affiliation:
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Department of Pharmacy, East West University, Mohakhali, Dhaka-1212, Bangladesh. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Markers / blood Carbon Tetrachloride Disease Models, Animal Drug-Induced Liver Injury Euphorbiaceae* / chemistry Hypnotics and Sedatives / pharmacology Liver / drug effects*, enzymology, pathology Liver Diseases / metabolism, pathology, prevention & control* Male Necrosis Phenobarbital / pharmacology Plant Components, Aerial Protective Agents / isolation & purification, pharmacology* Rats Rats, Long-Evans Sleep / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Hypnotics and Sedatives; 0/Protective Agents; 50-06-6/Phenobarbital; 56-23-5/Carbon Tetrachloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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