Document Detail

Hepatoprotective effect of syringic acid and vanillic acid on CCl4-induced liver injury.
MedLine Citation:
PMID:  20522963     Owner:  NLM     Status:  MEDLINE    
The mycelia of the edible mushroom Lentinula edodes can be cultured in solid medium containing lignin, and the hot-water extracts (L.E.M.) is commercially available as a nutritional supplement. During the cultivation, phenolic compounds, such as syringic acid and vanillic acid, were produced by lignin-degrading peroxidase secreted from L. edodes mycelia. Since these compounds have radical scavenging activity, we examined their protective effect on oxidative stress in mice with CCl(4)-induced liver injury. We examined the hepatoprotective effect of syringic acid and vanillic acid on CCl(4)-induced chronic liver injury in mice. The injection of CCl(4) into the peritoneal cavity caused an increase in the serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels. The intravenous administration of syringic acid and vanillic acid significantly decreased the levels of the transaminases. Four weeks of CCl(4) treatment caused a sufficiently excessive deposition of collagen fibrils. An examination of Azan-stained liver sections revealed that syringic acid and vanillic acid obviously suppressed collagen accumulation and significantly decreased the hepatic hydroxyproline content, which is the quantitative marker of fibrosis. Both of these compounds inhibited the activation of cultured hepatic stellate cells, which play a central role in liver fibrogenesis, and maintained hepatocyte viability. These data suggest that the administration of syringic acid and vanillic acid could suppress hepatic fibrosis in chronic liver injury.
Ayano Itoh; Katsuhiro Isoda; Masuo Kondoh; Masaya Kawase; Akihiro Watari; Masakazu Kobayashi; Makoto Tamesada; Kiyohito Yagi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biological & pharmaceutical bulletin     Volume:  33     ISSN:  1347-5215     ISO Abbreviation:  Biol. Pharm. Bull.     Publication Date:  2010  
Date Detail:
Created Date:  2010-06-04     Completed Date:  2011-01-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9311984     Medline TA:  Biol Pharm Bull     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  983-7     Citation Subset:  IM    
Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan.
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MeSH Terms
Biological Products / pharmacology,  therapeutic use*
Carbon Tetrachloride Poisoning / drug therapy*,  metabolism,  pathology
Collagen / metabolism
Drug-Induced Liver Injury, Chronic / drug therapy*,  metabolism,  pathology
Gallic Acid / analogs & derivatives*,  pharmacology,  therapeutic use
Hepatic Stellate Cells / drug effects,  metabolism
Hydroxyproline / metabolism
Liver / drug effects,  metabolism,  pathology
Liver Cirrhosis / prevention & control
Mice, Inbred BALB C
Rats, Sprague-Dawley
Shiitake Mushrooms*
Transaminases / metabolism
Vanillic Acid / pharmacology,  therapeutic use*
Reg. No./Substance:
0/Biological Products; 121-34-6/Vanillic Acid; 149-91-7/Gallic Acid; 51-35-4/Hydroxyproline; 530-57-4/syringic acid; 9007-34-5/Collagen; EC 2.6.1.-/Transaminases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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