| Hepatopathy-thrombocytopenia Syndrome (HTS) after Actinomycin-D Therapy: Report of Three Cases and Review of the Literature. | |
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MedLine Citation:
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PMID: 21271778 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Hepatopathy-thrombocytopenia syndrome (HTS) is a severe complication very similar to vein occlusive disease (VOD), also known as hepatic sinusoidal obstructive syndrome (SOS), characterized by fever, hepatopathy (hepatomegaly with abnormal liver function tests), ascites, weight gain, jaundice, and thrombocytopenia (platelet count less than 25 × 10(3)/μL). It has been generally observed in patients with Wilms tumor, and is commonly associated to administration of actinomycin D. We report three children with Wilms tumor, with severe HTS/SOS, but had a different outcome, in spite of vigorous supportive therapy. |
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Authors:
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Piero Farruggia; Alessandra Macaluso; Serena Tropia; Floriana Di Marco; Delia Russo; Antonella Grigoli; Antonino Trizzino; Paolo D'Angelo |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-27 |
Journal Detail:
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Title: Pediatric hematology and oncology Volume: - ISSN: 1521-0669 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8700164 Medline TA: Pediatr Hematol Oncol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Pediatric Hematology and Oncology, "G. Di Cristina" Children's Hospital, A.R.N.A.S., Palermo, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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