Document Detail


Hepatoma-derived growth factor involved in the carcinogenesis of gastric epithelial cells through promotion of cell proliferation by Erk1/2 activation.
MedLine Citation:
PMID:  18823380     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hepatoma-derived growth factor (HDGF) is related to tumorigenesis and the development of cancer; it is an independent factor associated with the prognosis of liver cancer, non-small cell lung cancer and pancreatic cancer. However, the molecular mechanism by which HDGF participates in gastric carcinogenesis and development as well as its functional regulation during the development of gastric precancerous lesions needs to be further analyzed. In the present study, we analyzed the effect of HDGF transfection on the proliferation and on the changes of mitogen-activated protein kinase (MAPK), Akt, and nuclear factor-kB (NF-kB) pathways in gastric cancer AGS cells. HDGF transfection significantly activated Erk1/2 in AGS cells and promoted anchorage-independent growth. Further studies showed that HDGF expression gradually increased in the gastric carcinogenesis process and HDGF showed a high expression in poorly differentiated adenocarcinoma prone to lymphoid metastasis; these findings suggest that HDGF is involved in the gastric carcinogenesis process and promotes proliferation and metastasis via Erk1/2 activation.
Authors:
Jianshan Mao; Zefeng Xu; Yongming Fang; Haijun Wang; Jinghong Xu; Jinjia Ye; Shu Zheng; Yongliang Zhu
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer science     Volume:  99     ISSN:  1349-7006     ISO Abbreviation:  Cancer Sci.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-12-05     Completed Date:  2009-01-23     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  101168776     Medline TA:  Cancer Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  2120-7     Citation Subset:  IM    
Affiliation:
Cancer Institute, Second Affiliated Hospital and Education Ministry Key laboratory of Cancer Prevention and Intervention, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / metabolism
Cell Line, Tumor
Cell Proliferation
Cell Transformation, Neoplastic / metabolism*
Epithelial Cells / cytology,  metabolism
Gastric Mucosa / enzymology*,  pathology
Humans
Intercellular Signaling Peptides and Proteins / metabolism*
Mitogen-Activated Protein Kinase 1 / metabolism*
Mitogen-Activated Protein Kinase 3 / metabolism*
NF-kappa B / metabolism
Proto-Oncogene Proteins c-akt / metabolism
Stomach Neoplasms / enzymology*,  metabolism,  pathology
Transfection
Chemical
Reg. No./Substance:
0/Intercellular Signaling Peptides and Proteins; 0/NF-kappa B; 0/hepatoma-derived growth factor; EC 2.7.11.1/Proto-Oncogene Proteins c-akt; EC 2.7.11.24/Mitogen-Activated Protein Kinase 1; EC 2.7.11.24/Mitogen-Activated Protein Kinase 3

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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