Document Detail


Hepatocyte polyploidy and metabolism/life-history traits: hypotheses testing.
MedLine Citation:
PMID:  8022197     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two alternate hypotheses explaining the causes of mammalian liver polyploidy have been tested by means of statistical analysis of more than 30 placental species. According to the first (general) hypothesis, the omission of mitosis is beneficial in rapidly growing and differentiating tissues that should early perform their specialized functions (economy on mitosis). In this case it is to be expected that the level of polyploidy is positively correlated to the rate of development. The second hypothesis suggests that hepatocyte polyploidy provides additional gene copies necessary under heavy chemical damage to metabolically active hepatocytes, which have to detoxicate noxious substances. In this case it is reasonable to expect that the level of liver ploidy is positively correlated with the rate of metabolism while inversely with the species lifespan (since it is usually assumed that DNA repair systems are more effective in more long-lived species). It is found that, if taken separately, the developmental rate, the rate of basal metabolism, the body weight (inversely), and the maximum lifespan (inversely) are all correlated with the level of hepatocyte polyploidy. However, all these parameters are intercorrelated. When the other parameters are fixed (in partial correlation analysis), only the developmental rate and the rate of basal metabolism remain significant predictors of the hepatocyte ploidy level, with only the former being a predictor of the nuclear ploidy level, while only the latter being positively correlated with the frequency of binucleated cells. These results suggest that relative importance of the two above explanations can differ for the different modes of liver cell polyploidy.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
O V Anatskaya; A E Vinogradov; B N Kudryavtsev
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of theoretical biology     Volume:  168     ISSN:  0022-5193     ISO Abbreviation:  J. Theor. Biol.     Publication Date:  1994 May 
Date Detail:
Created Date:  1994-08-03     Completed Date:  1994-08-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376342     Medline TA:  J Theor Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  191-9     Citation Subset:  IM    
Affiliation:
Institute of Cytology, Russian Academy of Sciences, St. Petersburg.
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MeSH Terms
Descriptor/Qualifier:
Animals
Basal Metabolism / genetics
Body Weight / genetics
Life Expectancy
Liver / cytology*,  growth & development,  metabolism
Mammals
Polyploidy*

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