| Hepatocyte growth factor and neuregulin in mammary gland cell morphogenesis. | |
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MedLine Citation:
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PMID: 10959405 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Organ culture and transplantation experiments in the early 1960s and 1970s have demonstrated that growth and morphogenesis of the epithelium of the mammary gland are controlled by mesenchymal-epithelial interactions. The identification of molecules that provide the essential signals exchanged in mesenchymal-epithelial interactions is an area of active research. Recent evidence suggests that morphogenic programs of epithelia can be triggered by mesenchymal factors that signal via tyrosine kinase receptors. This review concentrates on the effects of two mesenchymal factors, Hepatocyte Growth Factor/Scatter Factor and neuregulin, on morphogenesis and differentiation of mammary epithelial cells in vitro and signalling pathways involved during morphogenesis of mammary epithelial cells. |
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Authors:
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C Niemann; V Brinkmann; W Birchmeier |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Advances in experimental medicine and biology Volume: 480 ISSN: 0065-2598 ISO Abbreviation: Adv. Exp. Med. Biol. Publication Date: 2000 |
Date Detail:
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Created Date: 2000-12-01 Completed Date: 2000-12-01 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 0121103 Medline TA: Adv Exp Med Biol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 9-18 Citation Subset: IM |
Affiliation:
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Imperial Cancer Research Fund, Lincolns Inn Fields, London, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Differentiation / physiology Cells, Cultured Female Hepatocyte Growth Factor / physiology* Mammary Glands, Animal* / cytology, embryology, physiology Mice Morphogenesis Neuregulins / physiology* Signal Transduction |
| Chemical | |
Reg. No./Substance:
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0/Neuregulins; 67256-21-7/Hepatocyte Growth Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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