| Hepatocyte growth factor-mediated attraction of mesenchymal stem cells for apoptotic neuronal and cardiomyocytic cells. | |
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MedLine Citation:
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PMID: 19888551 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Human bone marrow-derived mesenchymal stem cells (MSC) home to injured tissues and have regenerative capacity. In this study, we have investigated in vitro the influence of apoptotic and necrotic cell death, thus distinct types of tissue damage, on MSC migration. Concordant with an increased overall motility, MSC migrated towards apoptotic, but not vital or necrotic neuronal and cardiac cells. Hepatocyte growth factor (HGF) was expressed by the apoptotic cells only. MSC, in contrast, revealed expression of the HGF-receptor, c-Met. Blocking HGF bioactivity resulted in significant reduction of MSC migration. Moreover, recombinant HGF attracted MSC in a dose-dependent manner. Thus, apoptosis initiates chemoattraction of MSC via the HGF/c-Met axis, thereby linking tissue damage to the recruitment of cells with regenerative potential. |
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Authors:
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Sebastian Vogel; Thorsten Trapp; Verena Börger; Corinna Peters; Dalila Lakbir; Dagmar Dilloo; Rüdiger V Sorg |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-11-03 |
Journal Detail:
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Title: Cellular and molecular life sciences : CMLS Volume: 67 ISSN: 1420-9071 ISO Abbreviation: Cell. Mol. Life Sci. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-21 Completed Date: 2010-01-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9705402 Medline TA: Cell Mol Life Sci Country: Switzerland |
Other Details:
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Languages: eng Pagination: 295-303 Citation Subset: IM |
Affiliation:
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Institute for Transplantation Diagnostics and Cell Therapeutics, Heinrich Heine University Medical Center, Moorenstrasse 5, Bldg. 14.80, 40225, Düsseldorf, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Apoptosis Cell Movement* Hepatocyte Growth Factor / genetics, pharmacology, physiology* Humans Mesenchymal Stem Cells / drug effects, metabolism, physiology* Myocytes, Cardiac / pathology*, physiology Necrosis / metabolism, pathology Neurons / pathology*, physiology Proto-Oncogene Proteins c-met / metabolism Regeneration* |
| Chemical | |
Reg. No./Substance:
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67256-21-7/Hepatocyte Growth Factor; EC 2.7.10.1/Proto-Oncogene Proteins c-met |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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