| Hepatocyte growth factor and left ventricular geometry in end-stage renal disease. | |
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MedLine Citation:
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PMID: 12511535 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hepatocyte growth factor is a pleiotropic cytokine with cardioprotective properties. Its serum concentration is markedly raised in end-stage renal disease. This study assessed the relation of hepatocyte growth factor (HGF) with left ventricular mass and geometry in end-stage renal disease. Serum HGF measurements and echocardiographic studies were performed in 185 patients receiving hemodialysis. Patients with serum HGF above the median (1.85 ng/mL) had more frequent cardiovascular complications. This cytokine was directly related to mean left ventricular wall thickness (r=0.23, P=0.002) and relative wall thickness (r=0.25, P=0.0001); a multivariate analysis showed that this relation was independent of other risk factors. Accordingly, the prevalence of left ventricular concentric geometry (either concentric left ventricular hypertrophy or remodeling) was much higher (n=49, 53%) among patients with HGF values above the median that in those with values < or =1.85 ng/mL (n=31, 34%). Furthermore, the risk for left ventricular concentric geometry was higher in patients with HGF values above the median (odds ratio, 2.57; 95% CI, 1.33 to 4.98; P=0.005), and multiple logistic regression analysis confirmed that this association was independent of other risk factors. In patients receiving hemodialysis, elevated serum HGF is associated with concentric left ventricular geometry. This is consistent with reports that link this cytokine to arterial remodeling and survival in patients with end-stage renal disease and suggests that it is part of a counterregulatory response aimed at attenuating cardiovascular damage in this high-risk population. |
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Authors:
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Lorenzo S Malatino; Alessandro Cataliotti; Francesco A Benedetto; Benedetta Stancanelli; Ignazio Bellanuova; Paola Belluardo; Lorena Bonaiuto; Giovanni Tripepi; Francesca Mallamaci; Pietro Castellino; Carmine Zoccali |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Hypertension Volume: 41 ISSN: 1524-4563 ISO Abbreviation: Hypertension Publication Date: 2003 Jan |
Date Detail:
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Created Date: 2003-01-03 Completed Date: 2003-01-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: United States |
Other Details:
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Languages: eng Pagination: 88-92 Citation Subset: IM |
Affiliation:
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Clinica Medica L. Condorelli, Department of Internal Medicine, University of Catania, Ospedale Vittorio Emanuele, Italy. dmalatin@tin.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Female Hepatocyte Growth Factor / blood* Humans Hypertrophy, Left Ventricular / etiology*, ultrasonography Kidney Failure, Chronic / blood, complications* Male Middle Aged Ventricular Remodeling* |
| Chemical | |
Reg. No./Substance:
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67256-21-7/Hepatocyte Growth Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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