Document Detail

Hepatocyte growth factor in human breast milk acts as a trophic factor.
MedLine Citation:
PMID:  11832996     Owner:  NLM     Status:  MEDLINE    
To evaluate the significance of hepatocyte growth factor (HGF) in milk in the perinatal period, we examined immunoreactive HGF levels and bioactivity in human milk. Human milk samples were obtained from women at various postpartum ages, and the levels of HGF were measured by ELISA. In the cross sectional study, the concentration of milk HGF from term deliveries showed a significant inverse correlation with progress of lactation, whereas in cases of preterm delivery concentrations, levels remained high after a long period of lactation. In the longitudinal analysis, the contents of HGF in colostrum, transitional, and mature milk from preterm deliveries were significantly be higher than those from term deliveries. Although mature milk from term and preterm deliveries contained significantly lower levels of HGF than colostrum, high levels of HGF persisted in mature milk from preterm deliveries. After partial purification, immunoblotting analysis showed the presence of both alpha- and beta-chains of HGF. HGF in milk stimulated proliferation of rat hepatocytes in primary culture, which was inhibited by supplementation with anti-HGF antibody. Thus, a high concentration of bioactive HGF is present in human milk in the postpartum period. Our results suggest that HGF in milk acts as a trophic factor for the gastrointestinal tract in neonates.
H Itoh; A Itakura; O Kurauchi; M Okamura; H Nakamura; S Mizutani
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme     Volume:  34     ISSN:  0018-5043     ISO Abbreviation:  Horm. Metab. Res.     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-02-08     Completed Date:  2002-04-30     Revised Date:  2009-02-19    
Medline Journal Info:
Nlm Unique ID:  0177722     Medline TA:  Horm Metab Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  16-20     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.
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MeSH Terms
Biological Assay
Blotting, Western
Cross-Sectional Studies
Digestive System Physiological Phenomena*
Enzyme-Linked Immunosorbent Assay
Epithelial Cells / physiology
Hepatocyte Growth Factor / immunology,  metabolism,  physiology*
Infant, Newborn
Longitudinal Studies
Milk, Human / chemistry*,  immunology,  metabolism
Reg. No./Substance:
67256-21-7/Hepatocyte Growth Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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