| Hepatocyte growth factor/scatter factor-Met signaling induces proliferation, migration, and morphogenesis of pancreatic oval cells. | |
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MedLine Citation:
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PMID: 8959349 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hepatocyte growth factor/scatter factor (HGF/SF) is a pleiotropic effector for cells expressing the Met tyrosine kinase receptor. In this investigation, we show that pancreatic oval cells express Met and exhibit a proliferative response to HGF/SF. Additionally, we found that oval cells treated transiently with this factor become "scattered," whereas those exposed to HGF/ SF for extended periods of time form branching tubular structures. These structures possess true lumens, which are lined by cells with ductal features, including apical microvilli, well-developed intercellular junctions, interdigitation of plasma membranes, and abundant cytoplasmic organelles. Interestingly, these ductal structures are formed by HGF/SF-treated cells cultured on plastic dishes in the absence of exogenous extracellular matrix components. Consistent with their ability to form ductal structures in vitro, we found that pancreatic oval cells form ductal adenocarcinomas in nude mice. This study supports the involvement of HGF/SF-Met signaling in the growth, migration, and morphogenesis of pancreatic oval cells and may have important implications for the expansion and morphogenic differentiation of these cells during developmental, regenerative, and neoplastic growth. |
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Authors:
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M Jeffers; M S Rao; S Rulong; J K Reddy; V Subbarao; E Hudson; G F Vande Woude; J H Resau |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research Volume: 7 ISSN: 1044-9523 ISO Abbreviation: Cell Growth Differ. Publication Date: 1996 Dec |
Date Detail:
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Created Date: 1997-03-07 Completed Date: 1997-03-07 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9100024 Medline TA: Cell Growth Differ Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1805-13 Citation Subset: IM |
Affiliation:
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Advanced BioScience Laboratories, Inc.-Basic Research Program, National Cancer Institute-Frederick Cancer Research and Development Center, Maryland 21702, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma Animals Antibody Specificity Blotting, Western Carcinogenicity Tests Cell Division / drug effects Cell Movement / drug effects* Cell Transplantation Cells, Cultured / chemistry, cytology, enzymology Copper / deficiency DNA / biosynthesis Fluorescent Antibody Technique Hepatocyte Growth Factor / pharmacology* Humans Mice Mice, Nude Microscopy, Electron Morphogenesis / drug effects Pancreas / cytology*, ultrastructure Rats Receptor Protein-Tyrosine Kinases / immunology, physiology* Signal Transduction / drug effects*, physiology |
| Grant Support | |
ID/Acronym/Agency:
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DK37958/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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67256-21-7/Hepatocyte Growth Factor; 7440-50-8/Copper; 9007-49-2/DNA; EC 2.7.10.1/Receptor Protein-Tyrosine Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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