Document Detail


Hepatocyte caspase-8 is an essential modulator of steatohepatitis in rodents.
MedLine Citation:
PMID:  23339067     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONCLUSION: Selective ablation of Casp8 in hepatocytes ameliorates development of NASH by modulating liver injury. Casp8-directed therapy might be a plausible treatment for patients with steatohepatitis. (HEPATOLOGY 2013;57:2189-2201).
Authors:
Maximilian Hatting; Gang Zhao; Fabienne Schumacher; Gernot Sellge; Malika Al Masaoudi; Nikolaus Gaβler; Mark Boekschoten; Michael Müller; Christian Liedtke; Francisco Javier Cubero; Christian Trautwein
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-05-06
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  57     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-06-13     Completed Date:  2013-08-16     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2189-201     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 American Association for the Study of Liver Diseases.
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis
Caspase 8 / metabolism*
Fatty Liver / enzymology*,  pathology
Fibrosis
Hepatocytes / enzymology*
Lipid Metabolism*
Liver / enzymology,  pathology
Male
Mice
Mice, Knockout
Oxidative Stress
Chemical
Reg. No./Substance:
EC 3.4.22.-/Casp8 protein, mouse; EC 3.4.22.-/Caspase 8

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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