Document Detail

Hepatocyte growth factor receptor, c-Met, in human embryo salivary glands. An immunohistochemical study.
MedLine Citation:
PMID:  20331593     Owner:  NLM     Status:  MEDLINE    
Salivary gland morphogenesis involves complex, coordinated events that include epithelial-mesenchymal interactions. Mesenchymal-epithelial transition factor (c-Met) is the hepatocyte growth factor (HGF) receptor. The latter is a hepatotropic factor originally identified in rat serum and platelets. It is essential in fetal tissue development, where it regulates complex morphogenetic processes including extracellular matrix invasion, cell migration, cell polarization and tubulogenesis. The c-Met/HGF system is believed to participate in epithelial-mesenchymal interactions during development. Twelve human embryonic minor salivary glands were studied by immunohistochemistry to investigate the role of c-Met in human salivary gland development. Strong c-Met immunopositivity in the glands demonstrated that the molecule is involved in their development and suggested a role for the c-Met/HGF system in this process.
C Loreto; R Caltabiano; G Musumeci; C Caltabiano; M G Greco; R Leonardi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-22
Journal Detail:
Title:  Anatomia, histologia, embryologia     Volume:  39     ISSN:  1439-0264     ISO Abbreviation:  Anat Histol Embryol     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-26     Completed Date:  2010-11-04     Revised Date:  2012-06-04    
Medline Journal Info:
Nlm Unique ID:  7704218     Medline TA:  Anat Histol Embryol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  173-7     Citation Subset:  IM    
Department of Anatomy, Diagnostic Pathology, Forensic Medicine, Hygiene and Public Health, University of Catania, 95123 Catania, Italy.
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MeSH Terms
Mesoderm / metabolism
Proto-Oncogene Proteins c-met / metabolism*
Receptors, Growth Factor / metabolism*
Salivary Glands / embryology*,  metabolism
Reg. No./Substance:
0/Receptors, Growth Factor; EC protein, human; EC Proteins c-met

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