Document Detail

Hepatocellular uptake of erythritol and mannitol in the dog.
MedLine Citation:
PMID:  1200166     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to determine the initial space of distribution of [14C]erythritol (mol wt 122) and [14C]mannitol (mol wt 182) in the liver of the dog by the single-injection, multiple-indicator-dilution method. 22Na was used as the extracellular indicator and tritiated water (THO) was used as total liver water indicator. The indicators were simultaneously injected into the portal vein of anesthetized dogs and dilution curves were obtained at the outflow from the hepatic vein. It was found that hepatic venous dilution curves of [14C]erythritol and THO were practically identical in all experiments. In contrast, the dilution curves of [14C]mannitol were generally distinct from those of THO. Analysis of [14C]mannitol-dilution curves according to Goresky suggested that the observed difference between this solute and THO was the result of a limited permeability of the sinusoidal membrane to mannitol. It is concluded that [14C]erythritol has instantaneous and practically unrestricted access to total liver water. This finding supports the validity of using erythritol as a liver cell water marker. A larger solute, [14C]mannitol, has restricted access to total liver cell water because of a permeability barrier in the sinusoidal liver cell membrane, but its diffusion into the hepatocyte is also very rapid.
J C Glasinovic; M Dumont; M Duval; S Erlinger
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The American journal of physiology     Volume:  229     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1975 Nov 
Date Detail:
Created Date:  1976-02-09     Completed Date:  1976-02-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1455-60     Citation Subset:  IM    
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MeSH Terms
Cell Membrane Permeability
Erythritol / metabolism*
Liver / metabolism*
Liver Circulation
Mannitol / metabolism*
Models, Biological
Reg. No./Substance:
149-32-6/Erythritol; 69-65-8/Mannitol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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