| Hepatocellular uptake of erythritol and mannitol in the dog. | |
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MedLine Citation:
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PMID: 1200166 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to determine the initial space of distribution of [14C]erythritol (mol wt 122) and [14C]mannitol (mol wt 182) in the liver of the dog by the single-injection, multiple-indicator-dilution method. 22Na was used as the extracellular indicator and tritiated water (THO) was used as total liver water indicator. The indicators were simultaneously injected into the portal vein of anesthetized dogs and dilution curves were obtained at the outflow from the hepatic vein. It was found that hepatic venous dilution curves of [14C]erythritol and THO were practically identical in all experiments. In contrast, the dilution curves of [14C]mannitol were generally distinct from those of THO. Analysis of [14C]mannitol-dilution curves according to Goresky suggested that the observed difference between this solute and THO was the result of a limited permeability of the sinusoidal membrane to mannitol. It is concluded that [14C]erythritol has instantaneous and practically unrestricted access to total liver water. This finding supports the validity of using erythritol as a liver cell water marker. A larger solute, [14C]mannitol, has restricted access to total liver cell water because of a permeability barrier in the sinusoidal liver cell membrane, but its diffusion into the hepatocyte is also very rapid. |
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Authors:
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J C Glasinovic; M Dumont; M Duval; S Erlinger |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The American journal of physiology Volume: 229 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1975 Nov |
Date Detail:
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Created Date: 1976-02-09 Completed Date: 1976-02-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1455-60 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Membrane Permeability Dogs Erythritol / metabolism* Liver / metabolism* Liver Circulation Mannitol / metabolism* Mathematics Models, Biological |
| Chemical | |
Reg. No./Substance:
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149-32-6/Erythritol; 69-65-8/Mannitol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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