| Hepatocellular carcinoma treatment with percutaneous ethanol injection: evaluation with contrast-enhanced color Doppler US. | |
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MedLine Citation:
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PMID: 9807563 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To investigate the ability of contrast agent-enhanced color Doppler ultrasonography (US) in evaluating the response of hepatocellular carcinoma (HCC) to percutaneous ethanol injection (PEI). MATERIALS AND METHODS: Forty-two patients (36 men, six women; age range, 51-79 years) with 54 1.3-7.0-cm-diameter (mean +/- SD, 2.8 cm +/- 1.1) HCC lesions were examined with contrast-enhanced color Doppler US before and after PEI. Spiral computed tomography (CT) and percutaneous biopsy also were performed to establish the outcome of therapy. RESULTS: Before PEI, intratumoral color signals were demonstrated at contrast-enhanced color Doppler US in 47 (87%) lesions (in 40 patients). After PEI, blood flow signals were no longer detected in all 34 of the lesions that were found to be necrotic at spiral CT and biopsy. In 12 (92%) of 13 lesions containing residual viable tumor, intratumoral color signals corresponding to the enhancing areas at spiral CT were still identified at contrast-enhanced color Doppler US. These 12 lesions were retreated with PEI by targeting the areas of residual tumor with contrast-enhanced color Doppler US guidance. Complete necrosis was seen after the second PEI cycle in nine of 12 lesions. CONCLUSION: Contrast-enhanced color Doppler US shows promise in assessing the therapeutic effect of PEI on HCC and in guiding additional treatment in cases of incomplete response. |
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Authors:
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C Bartolozzi; R Lencioni; P Ricci; A Paolicchi; P Rossi; R Passariello |
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Publication Detail:
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Type: Comparative Study; Journal Article; Multicenter Study |
Journal Detail:
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Title: Radiology Volume: 209 ISSN: 0033-8419 ISO Abbreviation: Radiology Publication Date: 1998 Nov |
Date Detail:
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Created Date: 1998-12-03 Completed Date: 1998-12-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0401260 Medline TA: Radiology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 387-93 Citation Subset: AIM; IM |
Affiliation:
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Department of Oncology, University of Pisa, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Biopsy Carcinoma, Hepatocellular / therapy*, ultrasonography* Contrast Media Ethanol / administration & dosage* Female Humans Injections, Intralesional Liver / pathology Liver Neoplasms / therapy*, ultrasonography* Male Middle Aged Polysaccharides / diagnostic use Tomography, X-Ray Computed Ultrasonography, Doppler, Color* |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Polysaccharides; 127279-08-7/SHU 508; 64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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