Document Detail

Hepatocellular carcinoma presenting with acquired porphyria: a case report and review of the literature.
MedLine Citation:
PMID:  10418219     Owner:  NLM     Status:  MEDLINE    
Hepatocellular carcinoma (HCC) with acquired porphyria is a very rare condition. It is characterized variably by hyperpigmentation, skin fragility and photodistributed subepidermal vesicles. The serum, urine and/or stool porphyrin levels, usually markedly elevated, can change according to the clinical course. We report here a case of hepatocellular carcinoma presenting with a paraneoplastic syndrome of acquired porphyria. A 73-year-old Chinese woman had the characteristic facial pigmentation of cutaneous porphyria and histologically proven hepatocellular carcinoma. Her serum zinc protoporphyrin was elevated and her urine tested positive for coproporphyrin. Her protoporphyrin and alpha-fetoprotein levels dropped after transarterial chemoembolization treatment. Acquired porphyria in hepatocellular carcinoma occurs exclusively in older persons with huge hepatocellular carcinoma and/or cirrhosis. Before diagnosis, it must be carefully differentiated from inherent porphyrias with HCC, and porphyrias induced by drugs or heavy metal intoxication must be ruled out.
W S Huang; L Y Liao; C S Wang; P H Chen
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Changgeng yi xue za zhi / Changgeng ji nian yi yuan = Chang Gung medical journal / Chang Gung Memorial Hospital     Volume:  22     ISSN:  -     ISO Abbreviation:  Changgeng Yi Xue Za Zhi     Publication Date:  1999 Mar 
Date Detail:
Created Date:  1999-08-05     Completed Date:  1999-08-05     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9809559     Medline TA:  Changgeng Yi Xue Za Zhi     Country:  CHINA (REPUBLIC: 1949- )    
Other Details:
Languages:  eng     Pagination:  111-6     Citation Subset:  IM    
Department of Gastroenterology, Chang Gung Memorial Hospital, Kaohsiung, Taipei Municipal Jen-Ai Hospital, Taiwan, R.O.C.
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MeSH Terms
Carcinoma, Hepatocellular / complications*
Liver Neoplasms / complications*
Porphyria Cutanea Tarda / etiology*

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