| Hepatocellular carcinoma: new options for image-guided ablation. | |
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MedLine Citation:
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PMID: 20091187 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Image-guided percutaneous ablation is currently accepted as the best therapeutic choice for patients with early-stage hepatocellular carcinoma (HCC) when transplantation and resection are precluded. Several methods for chemical or thermal tumor destruction have been developed and tested clinically during the past two decades. The seminal technique used for local treatment of HCC has been percutaneous ethanol injection (PEI). Several studies have provided indirect evidence that PEI improves the natural history of nonsurgical patients with early-stage HCC. Its major limitation is the high rate of local recurrence. Radiofrequency (RF) ablation has been the most widely assessed alternative to PEI. Five randomized controlled trials have shown that RF ablation achieves more effective and reproducible tumor destruction than PEI, leading to a better local control of the disease. As a result, RF ablation has been established as the primary ablative modality. The value of newer thermal and non-thermal methods for local tumor treatment, such as microwave ablation, irreversible electroporation (IRE), and light activated drug therapy, should be investigated in the setting of randomized controlled trials. |
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Authors:
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Riccardo Lencioni; Dania Cioni; Clotilde Della Pina; Laura Crocetti |
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Publication Detail:
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Type: Journal Article; Review Date: 2009-12-01 |
Journal Detail:
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Title: Journal of hepato-biliary-pancreatic sciences Volume: 17 ISSN: 1868-6982 ISO Abbreviation: J Hepatobiliary Pancreat Sci Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-08-17 Completed Date: 2011-01-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101528587 Medline TA: J Hepatobiliary Pancreat Sci Country: Japan |
Other Details:
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Languages: eng Pagination: 399-403 Citation Subset: IM |
Affiliation:
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Division of Diagnostic Imaging and Intervention, Department of Liver Transplantation, Hepatology, and Infectious Diseases, Pisa University School of Medicine, Cisanello Hospital, Building 30C, Suite 197, 56124 Pisa, Italy. lencioni@med.unipi.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carcinoma, Hepatocellular / surgery*, ultrasonography* Catheter Ablation / methods* Humans Liver Neoplasms / surgery*, ultrasonography* |
| Comments/Corrections | |
Erratum In:
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J Hepatobiliary Pancreat Sci. 2010 Jul;17(4):404 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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