Document Detail

Hepatocellular carcinoma in Wilson's disease. Case report and review of the literature.
MedLine Citation:
PMID:  2472436     Owner:  NLM     Status:  MEDLINE    
A 33-year-old man with Wilson's disease developed hemoptysis and radiographic evidence of nodular pulmonary infiltrates. A premortem diagnosis of hepatocellular carcinoma was made on the basis of alpha-naphthylannidase stains of pulmonary tissue obtained by open lung biopsy. We review all previous cases of Wilson's disease with this unusual complication and discuss the role of copper in hepatic oncogenesis as well as the alpha-naphthylannidase stain for the diagnosis of hepatocellular carcinoma.
J Polio; R E Enriquez; A Chow; W M Wood; C E Atterbury
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Journal of clinical gastroenterology     Volume:  11     ISSN:  0192-0790     ISO Abbreviation:  J. Clin. Gastroenterol.     Publication Date:  1989 Apr 
Date Detail:
Created Date:  1989-08-03     Completed Date:  1989-08-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7910017     Medline TA:  J Clin Gastroenterol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  220-4     Citation Subset:  IM    
Department of Medicine, Veterans Administration Medical Center, West Haven, Connecticut 06516.
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MeSH Terms
Carcinoma, Hepatocellular / pathology*
Hepatolenticular Degeneration / pathology*
Liver Neoplasms / pathology*
Staining and Labeling

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