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Hepatocellular carcinoma during pregnancy: is hepatocellular carcinoma more aggressive in pregnant patients?
MedLine Citation:
PMID:  21116657     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
BACKGROUND/PURPOSE: Hepatocellular carcinoma (HCC) during pregnancy is a very rare condition and is believed to have a worse prognosis than HCC in non-pregnant women. We evaluated the prognosis and the diagnostic and therapeutic strategies for HCC in pregnant women.
METHODS: We retrospectively analyzed 4 cases in our hospital and 44 cases described in the medical literature since 1957; we also compared the cases reported before 1995 and those reported during/after 1995.
RESULTS: The overall 6-month and 1-, 2-, and 3-year survival rates in the patients reported in the literature were 50, 29.5, 18.2, and 13.6%, respectively (n = 44). The mean ages at diagnosis before and during/after 1995 were 31.4 ± 7.2 and 28.9 ± 4.4 years, respectively (P = 0.113). The following characteristics were significantly more common in the later group: fewer pregnancies; the absence of advanced signs or symptoms; receipt of therapy; tendency to undergo surgery; and higher 6-month and 1-, 2-, and 3-year survival rates. The median survivals of the groups before and during/after 1995 were 18 and 25.5 months, respectively (P < 0.001).
CONCLUSIONS: The morbidity and mortality of HCC during pregnancy has improved over time, as diagnoses have tended to be made earlier and patients have tended to receive surgical and other treatments.
Authors:
Kang Kook Choi; Young Ju Hong; Sae Byeol Choi; Young Nyun Park; Jin Sub Choi; Woo Jung Lee; Kyung Sik Kim
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of hepato-biliary-pancreatic sciences     Volume:  18     ISSN:  1868-6982     ISO Abbreviation:  J Hepatobiliary Pancreat Sci     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-05-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101528587     Medline TA:  J Hepatobiliary Pancreat Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  422-31     Citation Subset:  IM    
Affiliation:
Kwandong Graduate School of Medicine, Gangneung-si, Gangwon-do, Korea.
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