| Hepatocellular carcinoma associated with hemophagocytic syndrome. | |
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MedLine Citation:
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PMID: 11677988 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hepatocellular carcinoma may manifest various paraneoplastic syndromes. There are some reports describing hematological change due to hepatocellular carcinoma. However, there have been no reports on hepatocellular carcinoma accompanied by hemophagocytic syndrome. We report here for the first time a 51-year-old man with a liver tumor and pancytopenia. Since the patient had showed a strong hemorrhagic diathesis because of thrombocytopenia, we treated him with blood transfusion, but there was no response. Thereafter, we administered the anticancer agents thinking that the hematological change was due to the liver tumor. Though a slight curative effect was obtained, we had to discontinue the treatment because the patient complained of severe side effects. Finally, the patient died of acute cholangitis. Although we could not determine the cause of the pancytopenia before he died, autopsy findings indicated that hemophagocytic syndrome had occurred. Hemophagocytic syndrome related to a solid tumor very rarely occurs. However, when malignant tumor is accompanied by pancytopenia, hemophagocytic syndrome should be considered. |
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Authors:
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T Sakai; K Shiraki; M Deguchi; N Itoh; T Konishi; K Takase; T Nakano |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Hepato-gastroenterology Volume: 48 ISSN: 0172-6390 ISO Abbreviation: Hepatogastroenterology Publication Date: 2001 Sep-Oct |
Date Detail:
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Created Date: 2001-10-25 Completed Date: 2002-02-08 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8007849 Medline TA: Hepatogastroenterology Country: Greece |
Other Details:
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Languages: eng Pagination: 1464-6 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Mie Prefectural General Medical Center, Mie, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bone Marrow
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pathology Carcinoma, Hepatocellular / pathology* Diagnosis, Differential Hemorrhagic Disorders / pathology Histiocytosis, Non-Langerhans-Cell / pathology* Humans Liver / pathology Liver Neoplasms / pathology* Male Middle Aged Pancytopenia / pathology Paraneoplastic Syndromes / pathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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