| Hepatocellular carcinoma in non-cirrhotic liver without evidence of iron overload in a patient with primary hemochromatosis. Review. | |
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MedLine Citation:
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PMID: 20872293 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: We report a case of a 70-year-old male with hepatocellular carcinoma (HCC) with a history of hemochromatosis but with no evidence of cirrhosis or iron overload and with a history of exposure to atomic bomb radiation. It is very rare to see hepatocellular carcinoma in the absence of evidence of liver injury. METHODS: We did an extensive review of current English medical literature through Pubmed from 1980 to 2009 and found 14 case reports of patient with hepatocellular cancer in absence of cirrhosis. The details of these cases were reanalyzed as reported and documented for review. RESULTS: There are 14 previous case reports of HCC developing in hemochromatosis in absence of cirrhosis but ten of them had evidence of iron overload in the non-tumorous livers. Our case is the fifth case of Hepatocellular cancer in hemochromatosis in absence of cirrhosis and iron overload. CONCLUSION: Hepatocellular carcinoma is a very rare in absence of cirrhosis but patient with other risk factors like hemochromatosis, viral infections, radiation, and toxin exposure should be monitored closely for any sign and symptoms suggestive of malignancy. |
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Authors:
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Parminder Singh; Harneet Kaur; Robert G Lerner; Roshan Patel; Shamudheen M Rafiyath; Gurpreet Singh Lamba |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Journal of gastrointestinal cancer Volume: 43 ISSN: 1941-6636 ISO Abbreviation: J Gastrointest Cancer Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-02-28 Completed Date: 2012-06-14 Revised Date: 2012-09-07 |
Medline Journal Info:
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Nlm Unique ID: 101479627 Medline TA: J Gastrointest Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 36-9 Citation Subset: IM |
Affiliation:
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Department of Hematology and Oncology, Westchester Medical Center, Valhalla, NY, USA. Drparminder.singh@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Carcinoma, Hepatocellular / etiology*, pathology Hemochromatosis / complications* Humans Liver Cirrhosis / complications Liver Neoplasms / etiology*, pathology Male Nuclear Warfare |
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