Document Detail

Hepatocellular carcinoma in a Hokkaido brown bear (Ursus arctos yesoensis).
MedLine Citation:
PMID:  20379082     Owner:  NLM     Status:  In-Process    
Hepatocellular carcinoma with metastases to lymph nodes and adrenal glands was found in a 26-year-old male Hokkaido brown bear (Ursus arctos yesoensis). Left hepatic lobe was largely replaced by well-differentiated neoplastic cells, whereas poorly differentiated tumor cells had proliferated in part of the left hepatic lobe, in scattered nodules in the remaining liver tissue, and at the metastatic sites. Immunoreactivity for hepatocyte antigen (hepatocyte paraffin 1 antibody) and alpha-fetoprotein was observed in both well- and poorly differentiated neoplastic cells in the liver and metastatic foci. To our knowledge, this case is the first report of hepatocellular carcinoma in brown bears.
Kazuya Matsuda; Yongjin Qiu; Yoshio Kawamura; Hiromi Suzuki; Yuko Takita; Hideyuki Sakamoto; Kazuyoshi Sasaki; Hiroyuki Taniyama
Publication Detail:
Type:  Journal Article     Date:  2010-04-07
Journal Detail:
Title:  The Journal of veterinary medical science / the Japanese Society of Veterinary Science     Volume:  72     ISSN:  0916-7250     ISO Abbreviation:  J. Vet. Med. Sci.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-10-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9105360     Medline TA:  J Vet Med Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1213-6     Citation Subset:  IM    
Department of Veterinary Pathology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan.
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