| Hepatocellular Carcinoma Presenting at Contrast-Enhanced Multi-Detector-Row Computed Tomography or Gadolinium-Enhanced Magnetic Resonance Imaging as a Small (≤2 cm), Indeterminate Nodule: Growth Rate and Optimal Interval Time for Imaging Follow-Up. | |
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MedLine Citation:
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PMID: 22261766 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVE: The objective of the study was to measure growth rate and to determine the optimal interval time for imaging follow-up of hepatocellular carcinomas (HCCs) presenting at multi-detector-row computed tomography (MDCT) or magnetic resonance imaging (MRI) as small, indeterminate lesions. METHODS: We included patients with cirrhosis with HCC initially presenting as indeterminate lesion of 2 cm or less at MDCT or MRI August 2005 to August 2009 and with available imaging follow-up. Measures of tumor growth included tumor volume doubling time (TVDT), tumor percentual diameter increase, and tumor percentual volume increase. RESULTS: We examined 48 patients (mean age, 64 years) with 69 HCCs. At index examination, mean (SD) maximum transverse diameter and volume of lesions were 1.2 (SD, 0.3) cm and 0.6 (SD, 0.7) cm, respectively. Median TVDT was 210 days. Tumors with follow-up longer than 365 days had significant increase in tumor percentual diameter increase and tumor percentual volume increase. CONCLUSIONS: Median TVDT of 210 days suggests extended follow-up of 6 months for small, indeterminate liver nodules detected at MDCT or MRI. |
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Authors:
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Alessandro Furlan; Daniele Marin; Francesco Agnello; Michele Di Martino; Vito Di Marco; Roberto Lagalla; Carlo Catalano; Giuseppe Brancatelli |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of computer assisted tomography Volume: 36 ISSN: 1532-3145 ISO Abbreviation: J Comput Assist Tomogr Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-01-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7703942 Medline TA: J Comput Assist Tomogr Country: United States |
Other Details:
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Languages: eng Pagination: 20-5 Citation Subset: IM |
Affiliation:
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From the *Department of Radiology, University of Pittsburgh Medical Center, Pittsburgh, PA; †Department of Radiology, Duke University Medical Center, Durham, NC; ‡Department of Radiological Sciences, University of Rome-La Sapienza, Rome; and §Department of Radiology, and ∥Sezione di Scienze Radiologiche, Di.Bi.Me.F., University of Palermo, Palermo, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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