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Hepatocarcinogenesis in liver cirrhosis: imaging diagnosis.
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MedLine Citation:
PMID:  9610609     Owner:  NLM     Status:  MEDLINE    
Hepatocellular carcinoma (HCC) frequently occurs in association with liver cirrhosis, as chronic liver disease is one of the most important factors in carcinogenesis. In addition to HCCs, recent reports of pathologic studies of resected specimens from cirrhotic liver describe associated small nodular lesions such as regenerative nodule, dysplastic nodule (adenomatous hyperplasia), and dysplastic nodule with subfocus of HCC (early HCC). In hepatocarcinogenesis of the cirrhotic liver, a regenerative nodule might be the first step in the development of HCC, going through phases of dysplastic nodule, early HCC and early advanced HCC in a multistep fashion. Fortunately, recent advances in various imaging techniques have facilitated the verification of these nodules. In this review, new nomenclature of small hepatocellular nodules, and detection and characterization of hepatic nodules in carcinogenesis with various imaging techniques are described with focus on the premalignant lesions and early stage of HCC. In addition, the efficacy of various imaging techniques for diagnosing them is discussed. Although the terms and definitions of these nodules are still variable and controversial, familiarity with the concept of these borderline lesions is important.
B I Choi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of Korean medical science     Volume:  13     ISSN:  1011-8934     ISO Abbreviation:  J. Korean Med. Sci.     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-08-10     Completed Date:  1998-08-10     Revised Date:  2011-03-16    
Medline Journal Info:
Nlm Unique ID:  8703518     Medline TA:  J Korean Med Sci     Country:  KOREA    
Other Details:
Languages:  eng     Pagination:  103-16     Citation Subset:  IM    
Department of Radiology and Institute of Radiation Medicine, Seoul National University College of Medicine, Korea.
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MeSH Terms
Carcinoma, Hepatocellular / complications,  diagnosis*,  pathology
Diagnostic Imaging* / methods
Liver Cirrhosis / complications,  diagnosis*,  pathology
Patient Care Management
Terminology as Topic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): J Korean Med Sci
Journal ID (pmc): jkms
ISSN: 1011-8934
ISSN: 1598-6357
Publisher: Korean Academy of Medical Sciences
Article Information
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Print publication date: Month: 4 Year: 1998
Volume: 13 Issue: 2
First Page: 103 Last Page: 116
ID: 3054481
PubMed Id: 9610609

Hepatocarcinogenesis in liver cirrhosis: imaging diagnosis.
B. I. Choi Email:
Department of Radiology and Institute of Radiation Medicine, Seoul National University College of Medicine, Korea.

Article Categories:
  • Research Article

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