| Hepatoblastoma in a patient with sotos syndrome. | |
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MedLine Citation:
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PMID: 19914434 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report a case of hepatoblastoma that developed in a child with Sotos syndrome, an overgrowth syndrome with an increased risk of neoplasms. Genome-wide analysis of copy number alterations showed a gain of chromosome 2, uniparental disomy of 18q, and microdeletion of 5q35. |
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Authors:
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Motohiro Kato; Junko Takita; Kan Takahashi; Masakazu Mimaki; Yuyan Chen; Katsuyoshi Koh; Kohmei Ida; Akira Oka; Masashi Mizuguchi; Seishi Ogawa; Takashi Igarashi |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Journal of pediatrics Volume: 155 ISSN: 1097-6833 ISO Abbreviation: J. Pediatr. Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-16 Completed Date: 2010-01-07 Revised Date: 2010-05-26 |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: United States |
Other Details:
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Languages: eng Pagination: 937-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatrics, Graduate school of Medicine, University of Tokyo, Tokyo, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Multiple
/
genetics,
pathology* Aneuploidy Chromosome Deletion Growth Disorders / complications, genetics, pathology* Hepatoblastoma / diagnosis, genetics*, therapy Humans Infant Intracellular Signaling Peptides and Proteins / genetics* Liver Neoplasms / diagnosis, genetics*, therapy Male Nuclear Proteins / genetics* Polymorphism, Single Nucleotide / genetics Syndrome |
| Chemical | |
Reg. No./Substance:
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0/Intracellular Signaling Peptides and Proteins; 0/NSD1 protein, human; 0/Nuclear Proteins |
| Comments/Corrections | |
Comment In:
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J Pediatr. 2010 Jun;156(6):1035-6; author reply 1036
[PMID:
20394943
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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