Document Detail

Hepatoblastoma in children of extremely low birth weight: a report from a single perinatal center.
MedLine Citation:
PMID:  12592636     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/PURPOSE: The incidence of hepatoblastoma (HB) in children of low birth weight is increasing. In the authors' institute, 5 infants of extremely low birth weight (ELBW) were found to have HB. The purpose of this study was to identify the characteristics of these infants to elucidate the pathogenesis of HB arising in ELBW infants. METHODS: Birth weight (BW) ranged from 554 to 750 g (mean, 654 g) and gestational age from 23 to 29 weeks (mean, 25.8 weeks). Medical records of the 5 patients were reviewed, and perinatal treatments were compared with those of ELBW infants without HB. RESULTS: One patient with intraabdominal hemorrhage had emergency operation, which was followed by early postoperative death. The parents of one child refused treatment because of associated severe anomalies. He died of the growing tumor 4 months after diagnosis. The remaining 3 patients had radical operation performed after intraarterial chemoembolization and systemic chemotherapy. One died of hepatic failure 7 months after operation. Two are alive 5 and 9 months after operation. The incidence of HB among ELBW infants was estimated to be about 0.5% in our institute. The mean durations of mechanical ventilation, oxygen inhalation, and hospitalization during the neonatal periods in cases of HB were significantly longer than those in BW matched control infants (P <.01). CONCLUSIONS: ELBW children have a high risk for HB. In follow-up of ELBW infants, serum alpha-fetoprotein or abdominal ultrasonography may be useful to detect early HB. The children with HB received perinatal treatments for a significantly longer time, which suggests that perinatal intensive and long-term medical treatments may be involved in the tumorigenesis in the highly sensitive immature liver.
Takaharu Oue; Akio Kubota; Hiroomi Okuyama; Hisayoshi Kawahara; Keigo Nara; Keisei Kawa; Hiroyuki Kitajima
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of pediatric surgery     Volume:  38     ISSN:  1531-5037     ISO Abbreviation:  J. Pediatr. Surg.     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2003-02-19     Completed Date:  2003-10-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0052631     Medline TA:  J Pediatr Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  134-7; discussion 134-7     Citation Subset:  IM    
Copyright Information:
Copyright 2003, Elsevier Science (USA). All rights reserved.
Department of Pediatric Surgery, Pediatrics and Neonatology, Osaka Medical Center & Research Institute for Maternal & Child Health, Izumi, Osaka, Japan.
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MeSH Terms
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Chemoembolization, Therapeutic / methods
Gestational Age
Hepatoblastoma / diagnosis,  drug therapy,  epidemiology*,  therapy
Infant, Newborn
Infant, Premature
Infant, Very Low Birth Weight*
Liver Neoplasms / diagnosis,  drug therapy,  epidemiology*,  therapy
Perinatal Care / methods

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