| Hepatoblastoma in a cat. | |
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MedLine Citation:
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PMID: 21118798 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Hepatoblastomas are neoplasms that originate from putative pluripotential stem cells of the liver. A hepatic mass from an 8-year-old Abyssinian cat was composed of cords and sheets of neoplastic cells, with scattered rosettes and small ductal structures. Most neoplastic cells had a pale eosinophilic cytoplasm and a round to ovoid nucleus. The tumor also had short spindle cells with an oval nucleus. Immunohistochemically, neoplastic cells were weakly positive for embryonic hepatocellular markers, such as alpha-fetoprotein and cytokeratin (CK) 8/18, but negative for the hepatocellular marker Hepatocyte Paraffin 1. The cells were also positive for CD56/neural cell adhesion molecule and for the biliary epithelial markers CK 7, CK 8/18, CK CAM5.2, and vimentin, but negative for CK 20. Some neoplastic cells expressed neuroectodermal or neuroendocrine markers, such as protein gene product 9.5 and synaptophysin, but were negative for chromogranin A and not argyrophilic by the Grimelius technique. The cat died soon after the biopsy without clinical improvement. |
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Authors:
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N Ano; K Ozaki; K Nomura; I Narama |
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Publication Detail:
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Type: Journal Article Date: 2010-11-29 |
Journal Detail:
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Title: Veterinary pathology Volume: 48 ISSN: 1544-2217 ISO Abbreviation: Vet. Pathol. Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-08-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0312020 Medline TA: Vet Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 1020-3 Citation Subset: IM |
Affiliation:
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Marupi Lifetech Co, Ltd, 103 Fushio-cho, Ikeda-shi, Osaka 563-0011, Japan Email: naoko-ano@ds-pharma.co.jp. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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